{"id":"W4412424979","doi":"10.1016/j.molmed.2025.06.008","title":"RNA immunotherapy: revolutionizing cancer and autoimmune disease treatments","year":2025,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"GlaxoSmithKline Biologicals; Canada Research Chairs; Faculté de pharmacie, Université de Montréal; Leslie Dan Faculty of Pharmacy, University of Toronto; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada","keywords":"Immunotherapy; Autoimmunity; Cancer immunotherapy; Immune system; RNA; Chimeric antigen receptor; Autoimmune disease; Cancer; Immunology; Cancer research; Biology; Medicine; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008444907,0.001085513,0.001239854,0.001365778,0.0002384835,0.001259115,0.001069683,0.001693935,0.005388742],"category_scores_gemma":[0.0008796159,0.0002186167,0.0003959794,0.001191331,0.0006445128,0.001432372,0.0007697796,0.003415656,0.003223653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007055071,"about_ca_system_score_gemma":0.001030482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006030797,"about_ca_topic_score_gemma":0.001636012,"domain_scores_codex":[0.999738,0.00004904089,0.00001748432,0.00003742077,0.0001206177,0.00003736439],"domain_scores_gemma":[0.9996775,0.0001602333,0.00003443247,0.000009683057,0.00006708867,0.00005104888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001043306,0.0001034718,0.00007883835,0.005833783,0.00005211095,0.0001209124,0.00002396968,0.0003534911,0.003528325,0.007761729,0.08870976,0.8933293],"study_design_scores_gemma":[0.00003239914,0.00007716655,0.0002233416,0.001025253,0.00005389118,0.0003833449,0.00002044542,0.0001234743,0.0005435989,0.002864651,0.9946404,0.00001215807],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008812665,0.9953619,0.0005225715,0.001033549,0.001100447,0.000006327625,0.00002424451,0.00002650601,0.001836449],"genre_scores_gemma":[0.0008099506,0.9946089,0.0005192743,0.001169279,0.001009497,0.00001301748,0.00005287962,0.000004531887,0.001812642],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005388742,"threshold_uncertainty_score":0.01802713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02531376976076617,"score_gpt":0.3554387983305692,"score_spread":0.3301250285698031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}