{"id":"W4412424979","doi":"10.1016/j.molmed.2025.06.008","title":"RNA immunotherapy: revolutionizing cancer and autoimmune disease treatments","year":2025,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"GlaxoSmithKline Biologicals; Canada Research Chairs; Faculté de pharmacie, Université de Montréal; Leslie Dan Faculty of Pharmacy, University of Toronto; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada","keywords":"Immunotherapy; Autoimmunity; Cancer immunotherapy; Immune system; RNA; Chimeric antigen receptor; Autoimmune disease; Cancer; Immunology; Cancer research; Biology; Medicine; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001346623,0.0004534104,0.0009669849,0.0003976345,0.00005292425,0.00001185993,0.0002702371,0.0002547488,0.00008417897],"category_scores_gemma":[0.00005254274,0.0003585163,0.0002326968,0.0003829063,0.0001417037,0.000003087895,0.0001314541,0.0002046274,0.00000287837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007874297,"about_ca_system_score_gemma":0.0002070065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001575879,"about_ca_topic_score_gemma":0.00002416232,"domain_scores_codex":[0.9982966,0.0001319296,0.0005021987,0.0006220057,0.0001529901,0.0002943429],"domain_scores_gemma":[0.9990828,0.00001583356,0.0001715446,0.0005947136,0.00003926029,0.00009587054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003352623,0.00004156716,0.00002511081,0.001334085,0.0003491791,0.00006922118,0.00002243097,0.000002100132,0.002027668,0.00001790924,0.0009029955,0.9951742],"study_design_scores_gemma":[0.001216126,0.0002397683,0.0004411052,0.02002745,0.001000862,0.00001271461,0.00001040818,0.000007564362,0.0001194162,0.00003511505,0.9764136,0.0004758617],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004671315,0.9977292,0.0001148073,0.0001813163,0.0002764693,0.0002354897,0.00005167828,0.0000126145,0.0009312393],"genre_scores_gemma":[0.0003284115,0.9900931,0.00007002011,0.0002399627,0.0001369933,0.000220865,0.0008288496,0.00004124316,0.008040524],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9946983,"threshold_uncertainty_score":0.9998867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02531376976076617,"score_gpt":0.3554387983305692,"score_spread":0.3301250285698031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}