{"id":"W4412426869","doi":"10.1128/spectrum.00876-25","title":"Essential histidine residues in Bombyx mori nucleopolyhedrovirus GP64 mediate pH-dependent membrane fusion","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Natural Science Foundation of China","keywords":"Histidine; Lipid bilayer fusion; Biology; Autographa californica; Mutant; Cell fusion; Virus; Cell membrane; Cell biology; Viral entry; Biochemistry; Biophysics; Cell; Amino acid; Virology; Viral replication; Gene; Spodoptera","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001830343,0.0002898264,0.0003148967,0.0002027712,0.0001599744,0.00002697018,0.000326366,0.0003711234,0.0003319561],"category_scores_gemma":[0.00007267667,0.0002723239,0.0001495286,0.0001971341,0.0001805503,0.000006182492,0.0003638892,0.0002191425,0.00006494659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006310271,"about_ca_system_score_gemma":0.0001362129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000458741,"about_ca_topic_score_gemma":0.001880107,"domain_scores_codex":[0.9981685,0.0001628448,0.0004041152,0.0006957968,0.00005964815,0.0005091312],"domain_scores_gemma":[0.9992558,0.00002090524,0.0001132949,0.0004885838,0.00003772741,0.00008363664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003884389,0.0001923393,0.006114104,0.00003042297,0.00006409413,0.00002813791,0.00002240299,0.00007372317,0.9773933,0.0002527453,0.01523165,0.0002086453],"study_design_scores_gemma":[0.001453677,0.0002623379,0.002826209,0.00004225732,0.0000307198,0.00003194048,0.0000344703,0.0000132032,0.9675728,0.0005948622,0.02683715,0.0003003937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909851,0.002771551,0.0001687267,0.0009533901,0.001561926,0.0002798295,0.00009734278,0.0000488159,0.003133329],"genre_scores_gemma":[0.9936337,0.0009193782,0.00006449697,0.0009439398,0.0003653142,0.00003529073,0.0003487893,0.00002583372,0.00366323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0116055,"threshold_uncertainty_score":0.9999729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003571604121953228,"score_gpt":0.2388312227286186,"score_spread":0.2352596186066654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}