{"id":"W4412426869","doi":"10.1128/spectrum.00876-25","title":"Essential histidine residues in Bombyx mori nucleopolyhedrovirus GP64 mediate pH-dependent membrane fusion","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Natural Science Foundation of China","keywords":"Histidine; Lipid bilayer fusion; Biology; Autographa californica; Mutant; Cell fusion; Virus; Cell membrane; Cell biology; Viral entry; Biochemistry; Biophysics; Cell; Amino acid; Virology; Viral replication; Gene; Spodoptera","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325768,0.000268812,0.0001066478,0.000118556,0.0001385788,0.000168554,0.0001454394,0.0001991417,0.0003667018],"category_scores_gemma":[0.0001203237,0.0001011306,0.0001658543,0.00009429027,0.0001971792,0.0001543625,0.0002476391,0.0002359573,0.0001960394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003539958,"about_ca_system_score_gemma":0.0001264033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009851631,"about_ca_topic_score_gemma":0.0008180268,"domain_scores_codex":[0.9999224,0.0000176347,0.000007116479,0.000009891878,0.00002195758,0.00002094366],"domain_scores_gemma":[0.9999181,0.00001577739,0.00002251368,0.000009056601,0.00000917553,0.00002532798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004947658,0.000008113368,0.0001927929,0.000009296613,0.000002254391,0.00003695281,0.000009563914,0.00005791281,0.9993278,0.00006251575,0.000005795521,0.00023765],"study_design_scores_gemma":[0.00002195823,0.0001812095,0.007000335,0.000005917355,0.00001415693,0.0002434853,0.00004404365,0.00224249,0.9894187,0.0001136664,0.0007086237,0.000005520739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990724,0.0001032199,0.0005696805,0.00001162717,0.00000242836,0.000005269575,0.0000341875,0.000008159188,0.0001930961],"genre_scores_gemma":[0.9990276,0.00008480722,0.000505046,0.000008724493,0.000001547064,0.000003981608,0.0001053379,0.000004210304,0.0002588015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009851631,"threshold_uncertainty_score":0.002568424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003571604121953228,"score_gpt":0.2388312227286186,"score_spread":0.2352596186066654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}