{"id":"W4412427036","doi":"10.1093/infdis/jiaf362","title":"Fetal Defects in Mice Treated With Integrase Strand Transfer Inhibitors: Comparison of Dolutegravir, Raltegravir, Bictegravir, and Cabotegravir","year":2025,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; Toronto General Hospital; University Health Network","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Ontario HIV Treatment Network","keywords":"Dolutegravir; Raltegravir; Emtricitabine; Biology; Medicine; Internal medicine; Virology; Viral load; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004661466,0.0006285584,0.000822422,0.001381436,0.0001914879,0.0003265818,0.0003786177,0.0006577947,0.001602868],"category_scores_gemma":[0.0003043932,0.0003512001,0.0005255385,0.0003089163,0.0005598294,0.000367866,0.0002266115,0.001205478,0.0002118933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004499073,"about_ca_system_score_gemma":0.0003002723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001054344,"about_ca_topic_score_gemma":0.001329623,"domain_scores_codex":[0.9994743,0.00008209149,0.00004784028,0.0001504925,0.0001299733,0.0001151971],"domain_scores_gemma":[0.9994655,0.00007814846,0.0001988201,0.00003598916,0.00003371415,0.0001878225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008939663,0.000909793,0.002874115,0.0001950731,0.00007291012,0.0002210443,0.00009288432,0.0003488882,0.9756352,0.0001742452,0.0002031863,0.010333],"study_design_scores_gemma":[0.0008386376,0.05259559,0.05093704,0.00008417665,0.0003817846,0.001850013,0.0002229384,0.002921444,0.8859368,0.0002020063,0.00396705,0.00006249723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941406,0.002114651,0.0009488325,0.0001147351,0.00004785739,0.00008361798,0.001150816,0.0001197207,0.001279183],"genre_scores_gemma":[0.987886,0.002816266,0.002777395,0.0001998917,0.0000355839,0.0003044281,0.001498035,0.0000573621,0.004425006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602868,"threshold_uncertainty_score":0.005362093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007115393526495005,"score_gpt":0.2626254984235981,"score_spread":0.2555101048971031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}