{"id":"W4412431037","doi":"10.1016/j.ejca.2025.115629","title":"Paediatric strategy forum for medicinal product development of cyclin-dependent kinase inhibitors in children and adolescents ACCELERATE in collaboration with the European Medicines Agency With participation of the Food and Drug Administration","year":2025,"lang":"en","type":"review","venue":"European Journal of Cancer","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Agenzia Italiana del Farmaco, Ministero della Salute; Loxo Oncology; National Institutes of Health; Cambridge University Hospitals; Solving Kids' Cancer; College ter Beoordeling van Geneesmiddelen; G1 Therapeutics; Institut Gustave-Roussy; Amsterdam University Medical Centers; Deutsches Krebsforschungszentrum; B-IT Foundation; Uniwersytet Jagielloński Collegium Medicum; Bundesinstitut für Arzneimittel und Medizinprodukte; National Cancer Center Japan; Karolinska Institutet; University of Minnesota; Memorial Sloan-Kettering Cancer Center; Centre Léon Bérard; Eli Lilly and Company; AstraZeneca; University of Cambridge; Children's Hospital of Philadelphia; Royal Marsden NHS Foundation Trust; Children's Hospital Colorado; Hospital for Sick Children; Pfizer","keywords":"Food and drug administration; Agency (philosophy); Product (mathematics); Drug; Medicine; Business; Regulatory agency; Pharmacology; Political science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002598606,0.0006521891,0.0007918095,0.001400618,0.0002409367,0.001020626,0.0007430692,0.001733983,0.01345626],"category_scores_gemma":[0.001406303,0.0001735436,0.0007421492,0.0009958787,0.0002620741,0.0008767445,0.0009324472,0.001844013,0.003108524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008867828,"about_ca_system_score_gemma":0.004381153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001824235,"about_ca_topic_score_gemma":0.003514054,"domain_scores_codex":[0.9994417,0.0001532549,0.00005600544,0.00004214924,0.0002205459,0.0000863484],"domain_scores_gemma":[0.9990572,0.0002263882,0.000256199,0.00002242383,0.0002745378,0.0001632105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002436092,0.0001539062,0.0001863054,0.01070222,0.00008130315,0.0002365077,0.00005832214,0.0002111472,0.003668344,0.007477202,0.1936827,0.7832985],"study_design_scores_gemma":[0.00009778892,0.0001226228,0.0004880206,0.002490212,0.00005742884,0.0002297309,0.00001401577,0.00004326824,0.0005133489,0.0004869263,0.9954512,0.000005432472],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007398572,0.9667516,0.001065517,0.00699181,0.002785935,0.0002886506,0.0007871685,0.00009834638,0.02049112],"genre_scores_gemma":[0.006859737,0.9641657,0.003733927,0.005683764,0.001011989,0.000223969,0.001083713,0.00002667294,0.01721051],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01345626,"threshold_uncertainty_score":0.04501563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851168105475782,"score_gpt":0.3160960032715867,"score_spread":0.2975843222168289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}