{"id":"W4412436457","doi":"10.1016/j.mayocpiqo.2025.100642","title":"Immunogenicity and Safety of ChAdOx1 nCoV-19 (AZD1222) as a Homologous Fourth-Dose Booster: A Substudy of the Phase 3 COV003 Trial in Brazil","year":2025,"lang":"en","type":"article","venue":"Mayo Clinic Proceedings Innovations Quality & Outcomes","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"Fundação Lemann; University of Oxford; AstraZeneca","keywords":"Immunogenicity; Medicine; Booster (rocketry); Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Booster dose; Coronavirus Infections; Virology; Pandemic; Betacoronavirus; Immunology; Internal medicine; Immunization; Infectious disease (medical specialty); Antigen; Aerospace engineering; Disease; Outbreak","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.005473968,0.0003064156,0.001278181,0.0007440813,0.0001977582,0.00003730246,0.0005152916,0.0002833406,0.00002484792],"category_scores_gemma":[0.01277246,0.000232256,0.0003133545,0.003316562,0.0006892425,0.0001719201,0.0004694532,0.0007630872,0.000006306091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002160467,"about_ca_system_score_gemma":0.001302517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001306985,"about_ca_topic_score_gemma":0.0001281251,"domain_scores_codex":[0.9955541,0.0001529905,0.002607538,0.0005540887,0.0007152139,0.0004160039],"domain_scores_gemma":[0.9960532,0.001404573,0.0008522257,0.0006083834,0.001043055,0.0000385436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03329568,0.003094138,0.9314615,0.0008341196,0.0004745047,0.000007620548,0.002465283,6.99569e-8,0.01276316,0.01178552,0.0003493443,0.003469075],"study_design_scores_gemma":[0.2018618,0.002339209,0.7442145,0.0006158031,0.0003623368,0.00004202948,0.004655813,0.0000601475,0.02849122,0.009911858,0.006943566,0.0005017042],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875675,0.0002042835,0.00004319335,0.005673395,0.0002989248,0.00262961,0.00005786204,0.00005288761,0.003472307],"genre_scores_gemma":[0.9813921,0.0000227208,0.0001868636,0.01771455,0.00003960256,0.0001698198,0.000006380385,0.0000210297,0.0004469375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.187247,"threshold_uncertainty_score":0.9955434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08267067014050773,"score_gpt":0.4710121085129448,"score_spread":0.3883414383724371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}