{"id":"W4412436877","doi":"10.1101/gr.280304.124","title":"Alternative splicing generates HER2 isoform diversity underlying antibody–drug conjugate resistance in breast cancer","year":2025,"lang":"en","type":"article","venue":"Genome Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Gene isoform; Biology; Trastuzumab; Alternative splicing; RNA splicing; Computational biology; Breast cancer; Cancer research; Receptor tyrosine kinase; Cancer; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001909331,0.000170698,0.0002181075,0.0003628518,0.0001398865,0.0004246249,0.0001398275,0.0002445611,0.0008767253],"category_scores_gemma":[0.0002666268,0.0001142533,0.0002365231,0.0004346732,0.0002075221,0.0001938866,0.0001647348,0.0003412631,0.0003602744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000259202,"about_ca_system_score_gemma":0.0001161026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003049547,"about_ca_topic_score_gemma":0.0004053736,"domain_scores_codex":[0.9998171,0.0000192727,0.00001412718,0.00005409948,0.00006770424,0.00002765243],"domain_scores_gemma":[0.9998668,0.00002550753,0.00005811937,0.00001280071,0.00002415914,0.00001242397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001746585,0.00003176002,0.01297674,0.00007843405,0.00002516326,0.000743721,0.0000950223,0.0003255562,0.9694482,0.0004642654,0.0003615216,0.01527497],"study_design_scores_gemma":[0.00004420239,0.0005055481,0.22328,0.00006223522,0.0001502221,0.01600722,0.0004373663,0.0080071,0.7188929,0.003140644,0.02943291,0.00003962976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916348,0.003024028,0.00297187,0.0001823933,0.0000170469,0.00001867015,0.0005494414,0.00005908206,0.001542643],"genre_scores_gemma":[0.9936365,0.002489668,0.001587991,0.0001873395,0.00002212057,0.00001669024,0.0009295568,0.00002601996,0.001104137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008767253,"threshold_uncertainty_score":0.002932966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09217154462663266,"score_gpt":0.4318592274840036,"score_spread":0.3396876828573709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}