{"id":"W4412441493","doi":"10.1016/j.cmet.2025.06.009","title":"Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication","year":2025,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"Diabetes Research Wellness Foundation; H2020 European Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; National Institutes of Health; National Institute for Health and Care Research; Novo Nordisk; Canadian Institutes of Health Research; Diabetes Research and Wellness Foundation; Deutsche Forschungsgemeinschaft; Diabetes UK; AstraZeneca; UK Research and Innovation; HORIZON EUROPE Framework Programme; Saint Mary's Foundation","keywords":"Alpha cell; Glucagon; Beta cell; Paracrine signalling; Cell biology; Internalization; Biology; Receptor; BETA (programming language); Endocrinology; Signal transduction; Internal medicine; Pancreatic islets; Islet; Alpha (finance); Insulin; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003466358,0.0002925776,0.0006688608,0.0003074053,0.0001389555,0.00006423159,0.0002716954,0.0001614027,0.0008017903],"category_scores_gemma":[0.0001921875,0.0002650059,0.0001697165,0.0006655887,0.00006059566,0.00009869827,0.0001264354,0.0002183863,0.0005664874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009312073,"about_ca_system_score_gemma":0.0001354973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002049597,"about_ca_topic_score_gemma":0.000004386479,"domain_scores_codex":[0.9981312,0.0002481855,0.0005307106,0.0004233596,0.000312192,0.000354345],"domain_scores_gemma":[0.9981096,0.0002354855,0.0001733865,0.000980761,0.0002189439,0.0002818549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001365268,0.001929199,0.01679614,0.001796977,0.0002868166,0.000007138804,0.00263335,0.0001703143,0.7088143,0.003629308,0.2541647,0.008406526],"study_design_scores_gemma":[0.003154368,0.00007014435,0.005333309,0.000242454,0.0006242246,7.842332e-7,0.0001423578,0.0008262848,0.5484699,0.0001629474,0.4407557,0.0002175083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6963056,0.01951015,0.01298579,0.001200405,0.001387873,0.001562043,0.00002234032,0.0003542361,0.2666716],"genre_scores_gemma":[0.8874309,0.001376395,0.007286608,0.003882766,0.0001692963,0.0001631496,0.0002090007,0.00005138294,0.0994305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1911253,"threshold_uncertainty_score":0.9999802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007956604009806988,"score_gpt":0.2561480570865111,"score_spread":0.2481914530767041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}