{"id":"W4412441493","doi":"10.1016/j.cmet.2025.06.009","title":"Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication","year":2025,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"Diabetes Research Wellness Foundation; H2020 European Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; National Institutes of Health; National Institute for Health and Care Research; Novo Nordisk; Canadian Institutes of Health Research; Diabetes Research and Wellness Foundation; Deutsche Forschungsgemeinschaft; Diabetes UK; AstraZeneca; UK Research and Innovation; HORIZON EUROPE Framework Programme; Saint Mary's Foundation","keywords":"Alpha cell; Glucagon; Beta cell; Paracrine signalling; Cell biology; Internalization; Biology; Receptor; BETA (programming language); Endocrinology; Signal transduction; Internal medicine; Pancreatic islets; Islet; Alpha (finance); Insulin; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006223129,0.0002531117,0.0002450786,0.0001280449,0.0001482228,0.000443712,0.0001545068,0.0002125503,0.001847184],"category_scores_gemma":[0.0001067709,0.0001011405,0.00023051,0.00007174606,0.0001577625,0.0002858587,0.0002359785,0.0005803748,0.0006401205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002419625,"about_ca_system_score_gemma":0.0001282204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000221163,"about_ca_topic_score_gemma":0.0003261928,"domain_scores_codex":[0.9999131,0.00001195286,0.000003183428,0.00002564646,0.00002040323,0.000025683],"domain_scores_gemma":[0.9999444,0.00001300427,0.00001431575,0.000008187652,0.000006765577,0.00001325256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005438007,0.00000653347,0.0001541904,0.00001699468,0.000002177625,0.00006781922,0.00001325015,0.00001872864,0.9985729,0.00007526229,0.00002567092,0.0009921023],"study_design_scores_gemma":[0.00001392545,0.0002833194,0.01925581,0.0000111968,0.00001575628,0.0006776881,0.0001323127,0.0009156026,0.9753356,0.0001499369,0.003199666,0.0000091119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882682,0.002827562,0.005332743,0.0001543612,0.00004523775,0.00001345738,0.0001422867,0.00009454757,0.003121628],"genre_scores_gemma":[0.9933627,0.001300481,0.002543773,0.0000809305,0.0000255542,0.00001235278,0.0001604514,0.00002003327,0.002493808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001847184,"threshold_uncertainty_score":0.006179452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007956604009806988,"score_gpt":0.2561480570865111,"score_spread":0.2481914530767041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}