{"id":"W4412442958","doi":"10.1016/j.jval.2025.04.1017","title":"HTA6 Real-World Evidence (RWE) in Health Technology Assessment (HTA): Global Guidelines on the Use of RWE in Evidence Generation for HTA Evaluation","year":2025,"lang":"en","type":"article","venue":"Value in Health","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Esri (Canada)","funders":"","keywords":"Real world evidence; Health technology; Medicine; Business; Risk analysis (engineering); Health care; Economic growth; Internal medicine; Economics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.2164138,0.003333305,0.01074855,0.01348344,0.002697746,0.01546318,0.009541578,0.02264745,0.05003535],"category_scores_gemma":[0.6092466,0.005315065,0.02950064,0.01864308,0.005915803,0.007062852,0.0123243,0.02487076,0.02082474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005803911,"about_ca_system_score_gemma":0.02675962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007980343,"about_ca_topic_score_gemma":0.008503267,"domain_scores_codex":[0.6133974,0.2557532,0.09206741,0.004193443,0.03171493,0.002873688],"domain_scores_gemma":[0.2893309,0.5848768,0.03897574,0.02481368,0.05760257,0.004400387],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001772275,0.0002424199,0.001288781,0.1612326,0.009797595,0.0005384368,0.002834386,0.003619148,0.00073989,0.06580925,0.4120666,0.3400586],"study_design_scores_gemma":[0.00328685,0.0004648994,0.004676236,0.2876627,0.01138592,0.0007415424,0.0005493517,0.003794827,0.001926449,0.1021732,0.5828402,0.0004978722],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.002011893,0.2120299,0.4065714,0.130748,0.01681504,0.04641605,0.0859722,0.00828845,0.09114703],"genre_scores_gemma":[0.01957594,0.0736433,0.7735051,0.03895811,0.00450442,0.05519683,0.02019291,0.003811475,0.01061185],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.7835862,"threshold_uncertainty_score":0.9663013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8745974336899165,"score_gpt":0.5982575559383363,"score_spread":0.2763398777515802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}