{"id":"W4412451603","doi":"10.1038/s41591-025-03834-0","title":"The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging","year":2025,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; Montreal Heart Institute","funders":"Robert Packard Center for ALS Research, Johns Hopkins University; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging; School of Public Health, Imperial College London; Instituto de Salud Carlos III; Wu Tsai Neurosciences Institute, Stanford University; Parkinsonfonden; University of California, San Francisco; School of Medicine, Emory University; National Center for Advancing Translational Sciences; Medical Research Council; Johnson and Johnson; National Institutes of Health; Université de Montréal; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Skånes universitetssjukhus; Alzheimer Nederland; Knut och Alice Wallenbergs Stiftelse; Janssen Research and Development; Generalitat de Catalunya; School of Medicine, Indiana University; Helsingin Yliopisto; GHR Foundation; European Commission; Sun Health Foundation; Vanderbilt University Medical Center; Lunds Universitet; Johns Hopkins University; Centers for Disease Control and Prevention; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Emory University; Wellcome Trust; University College London; Imperial College London; Faculty of Medicine and Health, University of Sydney; Vanderbilt University; Science for Life Laboratory; Vetenskapsrådet; Australian Government","keywords":"Neurodegeneration; Amyotrophic lateral sclerosis; Disease; Biomarker discovery; Biomarker; Proteomics; Frontotemporal dementia; Medicine; Dementia; Alzheimer's disease; Bioinformatics; Drug discovery; Computational biology; Biology; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001913825,0.0002048793,0.0003001538,0.00006556261,0.0004252092,0.00006861846,0.00006646219,0.00008317052,0.000002557425],"category_scores_gemma":[0.0004496134,0.0001154537,0.0000473672,0.0002167289,0.0004228836,0.0001225103,0.00007097155,0.000240642,3.293003e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005996869,"about_ca_system_score_gemma":0.0001756865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002843661,"about_ca_topic_score_gemma":0.00004148339,"domain_scores_codex":[0.9987583,0.0001117673,0.0002166781,0.0003733577,0.0002690536,0.0002708313],"domain_scores_gemma":[0.9989944,0.0003369645,0.00006450379,0.000239859,0.0001467824,0.0002174915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006215185,0.0005542518,0.8888863,0.0007658246,0.005683579,0.0002185581,0.0001968225,0.00000655548,0.004635791,0.02946634,0.04244545,0.02092538],"study_design_scores_gemma":[0.01668252,0.001029732,0.933817,0.0007619956,0.003415165,0.00009464923,0.0004381508,0.00603589,0.01119814,0.01422606,0.01186432,0.000436348],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8310613,0.1216543,0.0006467865,0.04321104,0.0004138033,0.002258855,0.0002521294,0.00005069595,0.000451123],"genre_scores_gemma":[0.9956786,0.001236473,0.0002618378,0.001905158,0.00021935,0.0001553636,0.0002324513,0.00001362867,0.0002971369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1646173,"threshold_uncertainty_score":0.4708065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138973878828891,"score_gpt":0.329092098290925,"score_spread":0.317702359502636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}