{"id":"W4412454913","doi":"10.1016/j.jaad.2025.07.013","title":"Highly selective, allosteric inhibition of TYK2 with oral ESK-001 in patients with moderate-to-severe plaque psoriasis: Results from STRIDE, a 12-week, randomized, double-blinded, placebo-controlled, dose-ranging phase 2 study","year":2025,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"","keywords":"Medicine; Plaque psoriasis; Placebo; Dose-ranging study; STRIDE; Dermatology; Psoriasis; Randomized controlled trial; Internal medicine; Pathology; Double blind; Physical medicine and rehabilitation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002383817,0.0008598033,0.001504903,0.0002481683,0.0002378322,0.0006945996,0.0005588103,0.00063502,0.002364798],"category_scores_gemma":[0.0008357199,0.0004570405,0.001337774,0.0002445329,0.0005871777,0.0006827299,0.0002806179,0.002247687,0.0004878248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003447929,"about_ca_system_score_gemma":0.0006378408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002291234,"about_ca_topic_score_gemma":0.0008255344,"domain_scores_codex":[0.999485,0.0002490814,0.00004747863,0.00007212234,0.00008906591,0.00005722713],"domain_scores_gemma":[0.9994973,0.0001136964,0.0001445154,0.00004635968,0.00003902763,0.0001590023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6441469,0.05454714,0.0114768,0.002296704,0.0031603,0.0003014868,0.0004313795,0.001753342,0.1161249,0.0002928984,0.00319594,0.1622723],"study_design_scores_gemma":[0.6217148,0.3328353,0.03327934,0.00009509445,0.00114732,0.0004466282,0.00007938674,0.001054243,0.006408071,0.0001758474,0.002722186,0.00004190435],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934668,0.003675858,0.000389251,0.0002359826,0.00005187916,0.0006889635,0.0002915659,0.00005899031,0.001140762],"genre_scores_gemma":[0.9938294,0.00230688,0.00103503,0.0005431345,0.0001031338,0.0007159167,0.0006186455,0.00001595107,0.0008317668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002383817,"threshold_uncertainty_score":0.01260698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497945779306086,"score_gpt":0.269397390435714,"score_spread":0.2544179326426532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}