{"id":"W4412463282","doi":"10.1016/j.lanmic.2025.101153","title":"Blood RNA biomarkers and C-reactive protein for triage of adult patients with tuberculosis lymphadenitis and pericarditis in South Africa: a single-centre, prospective, observational, diagnostic accuracy study","year":2025,"lang":"en","type":"article","venue":"The Lancet Microbe","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institutes of Health; Medical Research Council; South African Medical Research Council; National Institute of Allergy and Infectious Diseases; University College London Hospitals NHS Foundation Trust; European Commission; Royal College of Physicians; National Institute for Health and Care Research; University College London; European and Developing Countries Clinical Trials Partnership; Wellcome Trust","keywords":"Medicine; Observational study; Tuberculosis; Pericarditis; Triage; C-reactive protein; Tuberculous pericarditis; Prospective cohort study; Internal medicine; Pathology; Emergency medicine; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00224857,0.0005137897,0.0005685957,0.001044545,0.0004569227,0.0008781864,0.0006492392,0.0006288994,0.0006992928],"category_scores_gemma":[0.008192237,0.0005959262,0.0005968167,0.001273117,0.0005444226,0.0007963766,0.0007090035,0.0005987815,0.0001795475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005283739,"about_ca_system_score_gemma":0.0005437715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003407146,"about_ca_topic_score_gemma":0.003551387,"domain_scores_codex":[0.9980435,0.000728063,0.000276491,0.0004323777,0.0002942978,0.0002251342],"domain_scores_gemma":[0.9955472,0.0009751993,0.002517327,0.0003213481,0.0003334825,0.0003055189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001138808,0.00002820297,0.9991492,0.00001385549,0.00004737716,0.00004521018,0.00009252311,0.00001623488,0.000102769,0.00000462608,0.00002700744,0.0003589605],"study_design_scores_gemma":[0.00004098376,0.0002607628,0.9980749,0.00002855547,0.0000940532,0.0004276976,0.0003895784,0.000427634,0.0001096141,0.00001825486,0.0001211885,0.000006755388],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995086,0.0001668545,0.00008228713,0.00002157132,0.000002716342,0.00001554865,0.0001266728,0.000001098494,0.00007454277],"genre_scores_gemma":[0.9996682,0.0000565525,0.000117771,0.00001799501,0.0000060149,0.00001477444,0.00009957175,7.177556e-7,0.00001836672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003407146,"threshold_uncertainty_score":0.01189172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03214082212439716,"score_gpt":0.2879660787936029,"score_spread":0.2558252566692057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}