{"id":"W4412463282","doi":"10.1016/j.lanmic.2025.101153","title":"Blood RNA biomarkers and C-reactive protein for triage of adult patients with tuberculosis lymphadenitis and pericarditis in South Africa: a single-centre, prospective, observational, diagnostic accuracy study","year":2025,"lang":"en","type":"article","venue":"The Lancet Microbe","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institutes of Health; Medical Research Council; South African Medical Research Council; National Institute of Allergy and Infectious Diseases; University College London Hospitals NHS Foundation Trust; European Commission; Royal College of Physicians; National Institute for Health and Care Research; University College London; European and Developing Countries Clinical Trials Partnership; Wellcome Trust","keywords":"Medicine; Observational study; Tuberculosis; Pericarditis; Triage; C-reactive protein; Tuberculous pericarditis; Prospective cohort study; Internal medicine; Pathology; Emergency medicine; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000306502,0.0001718917,0.0006287509,0.0001305773,0.00008644944,0.0000207557,0.00009920648,0.00005990531,0.000004412239],"category_scores_gemma":[0.005285657,0.000110779,0.00004757814,0.0003871263,0.0002084876,0.00008373953,0.0001011618,0.0001357293,4.463757e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007700876,"about_ca_system_score_gemma":0.00007930779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001582271,"about_ca_topic_score_gemma":0.0001060093,"domain_scores_codex":[0.9986027,0.0002396627,0.000306665,0.0003559782,0.0001482754,0.0003466454],"domain_scores_gemma":[0.9973451,0.00192523,0.0001291399,0.0002422477,0.0002943526,0.00006389146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002388263,0.001130371,0.9841366,0.0002291626,0.0006855408,0.000008565507,0.002963679,6.061406e-7,0.006701734,0.00008679921,0.0007163422,0.0009522967],"study_design_scores_gemma":[0.01635353,0.001100525,0.9775444,0.0004122779,0.0003335829,0.000003910474,0.001468928,0.00001906709,0.002329544,0.0001679396,0.0001523129,0.0001139342],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990926,0.0005646501,0.00002105719,0.00318528,0.00001575419,0.004883641,0.0001943083,0.00001635351,0.0001929049],"genre_scores_gemma":[0.9983068,0.00004963404,0.0005630535,0.0003104897,0.0000375084,0.0006287604,0.00003588882,0.00001522607,0.00005266099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01396527,"threshold_uncertainty_score":0.6327807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03214082212439716,"score_gpt":0.2879660787936029,"score_spread":0.2558252566692057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}