{"id":"W4412464331","doi":"10.1002/pul2.70126","title":"Enhancing Drug Development for Paediatric Pulmonary Hypertension—An Integrative Perspective","year":2025,"lang":"en","type":"review","venue":"Pulmonary Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"","keywords":"Medicine; Clinical trial; Intensive care medicine; Observational study; Drug development; Disease; Drug; Pediatrics; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005505221,0.0006455972,0.001339575,0.002005703,0.0003832465,0.003649564,0.0009137596,0.001800022,0.004379733],"category_scores_gemma":[0.006095204,0.000222727,0.0008160351,0.001375167,0.0009507237,0.003276648,0.002072438,0.003117212,0.001273518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009046433,"about_ca_system_score_gemma":0.003267066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000567303,"about_ca_topic_score_gemma":0.001196632,"domain_scores_codex":[0.997768,0.001122009,0.0002766077,0.000192853,0.0004822822,0.0001580793],"domain_scores_gemma":[0.9930499,0.00447332,0.0006970644,0.0001879185,0.001178816,0.0004130583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001840866,0.000191749,0.0005499292,0.01992935,0.0002210595,0.0002269826,0.0004248673,0.000536906,0.002117946,0.02835982,0.02356391,0.9236935],"study_design_scores_gemma":[0.00009027817,0.0005884469,0.00101256,0.01322679,0.000291011,0.0007560989,0.0003363011,0.0002989053,0.0007647972,0.01315993,0.9694446,0.00003020542],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000610382,0.9846682,0.001357369,0.007956105,0.0005916516,0.00003622215,0.00004165829,0.00003295716,0.004705335],"genre_scores_gemma":[0.006052278,0.9852124,0.003140497,0.003706013,0.0009196997,0.00005271173,0.00006051972,0.00001180663,0.0008440717],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005505221,"threshold_uncertainty_score":0.02911472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04449440799739534,"score_gpt":0.3460732586154158,"score_spread":0.3015788506180204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}