{"id":"W4412473303","doi":"10.3390/vaccines13070757","title":"Optimization of YF17D-Vectored Zika Vaccine Production by Employing Small-Molecule Viral Sensitizers to Enhance Yields","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Vancouver Biotech (Canada)","funders":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology","keywords":"Bioprocess; Cell culture; Viral replication; Zika virus; Titer; Biology; Viral vector; Innate immune system; Virology; Chemistry; Cell biology; Virus; Recombinant DNA; Immunology; Immune system; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005958691,0.0007416515,0.0004784128,0.0003773718,0.0001600111,0.0008778827,0.0004207543,0.0004408779,0.001092571],"category_scores_gemma":[0.0004538162,0.0002378892,0.0005216554,0.0002968243,0.0002424031,0.0004175804,0.0003741461,0.0006655536,0.0006843403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005445619,"about_ca_system_score_gemma":0.0002606562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004016391,"about_ca_topic_score_gemma":0.0007010277,"domain_scores_codex":[0.9996579,0.00003964459,0.00005198808,0.00007843336,0.0001052421,0.0000669147],"domain_scores_gemma":[0.9998264,0.00004954793,0.00004593096,0.00001990975,0.00003746735,0.00002083545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003809759,0.00002932639,0.0001240079,0.00005773103,0.00000585419,0.00002650551,0.00001541744,0.0004516274,0.9976419,0.00006856475,0.00002768201,0.001513392],"study_design_scores_gemma":[0.000005729712,0.0001876123,0.0004118015,0.000006046625,0.00001411771,0.00003681633,0.000009230092,0.001153274,0.9969491,0.00001983518,0.001201125,0.00000528545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96736,0.001347463,0.02769875,0.00009793565,0.00004744023,0.0002733876,0.0006955213,0.0003365585,0.002143048],"genre_scores_gemma":[0.9350161,0.001949799,0.05915897,0.00004661445,0.000009407559,0.0002828694,0.001200095,0.000143772,0.002192341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092571,"threshold_uncertainty_score":0.003951073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005263197964291348,"score_gpt":0.2665572495910638,"score_spread":0.2612940516267724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}