{"id":"W4412473414","doi":"10.3390/genes16070818","title":"Brain and CSF Alzheimer’s Biomarkers Are Associated with SERPINE1 Gene Expression","year":2025,"lang":"en","type":"article","venue":"Genes","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Center for Diagnosis and Research on Alzheimer's Disease; McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Olav Thon Stiftelsen; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Familjen Erling-Perssons Stiftelse","keywords":"Biomarker; Plasminogen activator inhibitor-1; Internal medicine; Pathology; Medicine; Pathological; Endocrinology; Oncology; Biology; Plasminogen activator; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001644162,0.0003045773,0.000211638,0.0009259281,0.0001642,0.0005404773,0.0001117211,0.0002672865,0.001764946],"category_scores_gemma":[0.0009278401,0.0001125559,0.0001561888,0.0003994862,0.0002953443,0.0001564086,0.0001732508,0.0002730643,0.0002848382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002538036,"about_ca_system_score_gemma":0.0001452896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001723183,"about_ca_topic_score_gemma":0.001456085,"domain_scores_codex":[0.9998677,0.00001786271,0.000009334052,0.00004335576,0.00003932958,0.00002243982],"domain_scores_gemma":[0.9993685,0.0001216744,0.0002961728,0.00004105336,0.0000846351,0.00008801094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004725258,0.0001540283,0.5568873,0.0001327597,0.0002520223,0.001282104,0.000527892,0.0001899398,0.4136963,0.0002053437,0.0006365668,0.02131038],"study_design_scores_gemma":[0.00001535487,0.0001233385,0.9830168,0.000009753642,0.00004227458,0.0009796111,0.0000890868,0.0001668892,0.01496416,0.0001643169,0.0004219865,0.000006535809],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981837,0.0004161484,0.000267722,0.00003015957,0.000005631323,0.000006021912,0.0004130525,0.00001715115,0.0006605677],"genre_scores_gemma":[0.9980614,0.0002257062,0.0004947364,0.00002789659,0.00001264384,0.00001227874,0.0004500146,0.000009136404,0.0007062946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001764946,"threshold_uncertainty_score":0.005904377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02981324472788478,"score_gpt":0.3135727206139675,"score_spread":0.2837594758860827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}