{"id":"W4412473414","doi":"10.3390/genes16070818","title":"Brain and CSF Alzheimer’s Biomarkers Are Associated with SERPINE1 Gene Expression","year":2025,"lang":"en","type":"article","venue":"Genes","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Center for Diagnosis and Research on Alzheimer's Disease; McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Olav Thon Stiftelsen; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Familjen Erling-Perssons Stiftelse","keywords":"Biomarker; Plasminogen activator inhibitor-1; Internal medicine; Pathology; Medicine; Pathological; Endocrinology; Oncology; Biology; Plasminogen activator; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008806723,0.0001447648,0.0002094722,0.0001159484,0.0001255218,0.00002484648,0.00004725105,0.00007001377,0.00004945252],"category_scores_gemma":[0.00006482159,0.0001006993,0.00004234934,0.0002222029,0.00008639738,0.00005908581,0.00005711475,0.00006083099,0.00001163228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003237206,"about_ca_system_score_gemma":0.0001454492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003691137,"about_ca_topic_score_gemma":0.00002655704,"domain_scores_codex":[0.9990821,0.00005754406,0.0001096109,0.0002744115,0.0002155977,0.00026072],"domain_scores_gemma":[0.9993684,0.00007213205,0.00004723008,0.0002141697,0.0000884869,0.0002095252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00149632,0.000668756,0.9102904,0.00009227858,0.02892668,0.000666581,0.00008798172,0.000002198069,0.01670074,0.00002167498,0.02279514,0.01825131],"study_design_scores_gemma":[0.007225125,0.0004400576,0.8783426,0.0008218981,0.001904721,0.0000287666,0.0003288526,0.000176055,0.1084237,0.0002026569,0.001827217,0.0002783509],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9422232,0.05365993,0.00003727032,0.002291929,0.00004286935,0.0004726868,0.00005332348,0.00008726661,0.001131517],"genre_scores_gemma":[0.9982146,0.0003548391,0.0003993498,0.0004600257,0.00003151565,0.00005024395,0.0001367636,0.00001763702,0.0003350479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09172298,"threshold_uncertainty_score":0.4106398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02981324472788478,"score_gpt":0.3135727206139675,"score_spread":0.2837594758860827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}