{"id":"W4412479640","doi":"10.1001/jamanetworkopen.2025.21197","title":"Pathologic Complete Response and Survival in Rectal Cancer","year":2025,"lang":"en","type":"review","venue":"JAMA Network Open","topic":"Colorectal Cancer Surgical Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Internal medicine; Colorectal cancer; Hazard ratio; Grading (engineering); Meta-analysis; Neoadjuvant therapy; Randomized controlled trial; Odds ratio; Oncology; Confidence interval; Cancer; Surgery; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001616575,0.0004558041,0.00293221,0.0001438933,0.00007396428,0.0001215759,0.0003925837,0.0004411743,0.0003372045],"category_scores_gemma":[0.0003679138,0.0003351152,0.0002384767,0.0009758449,0.00008317921,0.00007567111,0.001023843,0.0007217796,0.00002774433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006045555,"about_ca_system_score_gemma":0.0008582842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004334075,"about_ca_topic_score_gemma":0.0004130872,"domain_scores_codex":[0.9963996,0.001535155,0.0006200729,0.0007547653,0.0002140097,0.0004764266],"domain_scores_gemma":[0.9971259,0.001979656,0.0002248539,0.0004588716,0.00004687463,0.0001638113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003816777,0.00007310296,0.003977582,0.003621866,0.0002157473,0.001852702,0.00003446202,0.000002368351,4.831251e-8,0.00002846386,0.002326547,0.9840503],"study_design_scores_gemma":[0.001933976,0.0003093889,0.02424305,0.04656336,0.0005703882,0.0001162648,0.000007459255,0.000007406102,2.610257e-8,0.0000562368,0.9259067,0.0002857899],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009552533,0.9788951,7.772056e-7,0.0003964174,0.0005855437,0.003291376,0.0001414958,0.00003552228,0.01569857],"genre_scores_gemma":[0.0002069693,0.9930544,0.000212908,0.0003100604,0.0003482825,0.001285849,0.000138104,0.00004245483,0.004400936],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9837645,"threshold_uncertainty_score":0.9999101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1171111219559711,"score_gpt":0.4273304946100381,"score_spread":0.310219372654067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}