{"id":"W4412482968","doi":"10.1093/pnasnexus/pgaf216","title":"Modulation of immunoglobulin G oligomerization by variable domain glycans: A mechanism to regulate complement activation","year":2025,"lang":"en","type":"article","venue":"PNAS Nexus","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"ReumaNederland; European Commission; Leids Universitair Medisch Centrum; ZonMw; European Research Council; Universiteit Leiden; Netherlands Centre for Electron Nanoscopy","keywords":"Complement system; Cell biology; Antibody; Classical complement pathway; Chemistry; Immune system; Effector; Autoantibody; Function (biology); Immunoglobulin G; Antigen; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001455151,0.0002117616,0.000123579,0.0001211846,0.0001068058,0.0002932828,0.000196564,0.000267152,0.0003075999],"category_scores_gemma":[0.0001002641,0.00005979867,0.0001366709,0.00009610306,0.0002616749,0.000187146,0.0001682154,0.0002512704,0.00006469238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004400052,"about_ca_system_score_gemma":0.0001873623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004754309,"about_ca_topic_score_gemma":0.0004737705,"domain_scores_codex":[0.9999211,0.00001697027,0.000003176805,0.00001644087,0.000019548,0.00002269595],"domain_scores_gemma":[0.999962,0.000006623652,0.00001254777,0.000004925003,0.000005721222,0.000008197328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004301359,0.00001149552,0.0002223801,0.00001729057,0.000003380046,0.00002400029,0.000007376704,0.00009269969,0.9979678,0.000340541,0.00001516909,0.001254807],"study_design_scores_gemma":[0.00001251254,0.0001627408,0.004002385,0.000004099266,0.000008235547,0.0001188628,0.00001813592,0.001185062,0.9931843,0.0002156317,0.001084328,0.000003764637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992706,0.00248405,0.003691529,0.00009925525,0.00001470114,0.00001601581,0.00004269493,0.00002758033,0.0009181545],"genre_scores_gemma":[0.997748,0.0004958393,0.001228791,0.00004350328,0.000004261226,0.000005679682,0.00002060843,0.000002948812,0.0004504024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004754309,"threshold_uncertainty_score":0.003192425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01381970452548911,"score_gpt":0.3046381882709858,"score_spread":0.2908184837454967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}