{"id":"W4412486967","doi":"10.1002/glia.70055","title":"Microglial Activation and Inflammatory Responses in Parkinson's Disease Models Are Attenuated by <scp>TRPM2</scp> Depletion","year":2025,"lang":"en","type":"article","venue":"Glia","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Microglia; TRPM2; Inflammation; Biology; Proinflammatory cytokine; Context (archaeology); CD68; Neuroinflammation; Substantia nigra; Transient receptor potential channel; Cell biology; Neuroscience; Immunology; Receptor; Immunohistochemistry; Dopamine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001850155,0.0005359744,0.0006406918,0.0004187867,0.0002741589,0.0003332765,0.0002026109,0.0004946839,0.001414565],"category_scores_gemma":[0.0001212785,0.0001632575,0.0004336594,0.0002538152,0.0004327637,0.0003197476,0.0002037735,0.0009024307,0.0004168666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002628739,"about_ca_system_score_gemma":0.0002653838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006192676,"about_ca_topic_score_gemma":0.001211743,"domain_scores_codex":[0.9997142,0.00003400444,0.00003799509,0.00006273891,0.00008957832,0.00006143677],"domain_scores_gemma":[0.9998701,0.00001183765,0.00004736095,0.00001664615,0.00001739641,0.0000367734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001802976,0.00002889257,0.0001036678,0.00004164293,0.00000760901,0.00006425747,0.00001566465,0.00002324082,0.9987393,0.00003511613,0.00005107047,0.0007093271],"study_design_scores_gemma":[0.00002933564,0.0003394188,0.004337864,0.00001037989,0.00003613604,0.0005306844,0.00003770031,0.000463203,0.9918389,0.00005181687,0.002317715,0.000006896836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911273,0.002103216,0.003794319,0.000270583,0.00005771999,0.00004245348,0.001049048,0.0002206747,0.001334583],"genre_scores_gemma":[0.988172,0.001685443,0.004159673,0.000148909,0.00003933826,0.0001978894,0.001386122,0.00009283431,0.004117751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001414565,"threshold_uncertainty_score":0.004732192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02104159266190253,"score_gpt":0.2448762316505035,"score_spread":0.223834638988601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}