{"id":"W4412486967","doi":"10.1002/glia.70055","title":"Microglial Activation and Inflammatory Responses in Parkinson's Disease Models Are Attenuated by <scp>TRPM2</scp> Depletion","year":2025,"lang":"en","type":"article","venue":"Glia","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Microglia; TRPM2; Inflammation; Biology; Proinflammatory cytokine; Context (archaeology); CD68; Neuroinflammation; Substantia nigra; Transient receptor potential channel; Cell biology; Neuroscience; Immunology; Receptor; Immunohistochemistry; Dopamine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001880771,0.000176252,0.0001431116,0.0002826564,0.0001843835,0.000120979,0.0001378943,0.00007702176,0.000007586586],"category_scores_gemma":[0.001243876,0.0001914371,0.00003386891,0.0003494001,0.00005894243,0.0004489779,0.00006777373,0.0001723324,0.00001999474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004867254,"about_ca_system_score_gemma":0.00007572556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005978849,"about_ca_topic_score_gemma":0.00001435451,"domain_scores_codex":[0.9983284,0.0003675437,0.0002951763,0.0005202507,0.000237112,0.0002514692],"domain_scores_gemma":[0.9991643,0.000297349,0.0001412999,0.0002362141,0.00004137239,0.0001194149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001053832,0.00004413083,0.002354175,0.0000263422,0.000001246089,0.00002681461,0.00008784863,0.0002388803,0.9890582,0.003124229,0.004663502,0.0002692807],"study_design_scores_gemma":[0.0007793845,0.00001967335,0.01359156,0.00004770603,0.000006984984,0.000002615871,0.00002938117,0.01429489,0.9562721,0.002646944,0.01222528,0.00008349775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956116,0.00003539155,0.002140471,0.001136474,0.0002394533,0.0004091865,0.00006080711,0.0001571791,0.0002094239],"genre_scores_gemma":[0.9944254,0.000117491,0.00005494411,0.002498163,0.00003236698,0.00006244452,0.00001500392,0.00001876741,0.002775407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03278609,"threshold_uncertainty_score":0.7806577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02104159266190253,"score_gpt":0.2448762316505035,"score_spread":0.223834638988601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}