{"id":"W4412487863","doi":"10.1093/braincomms/fcaf222","title":"The lifetime accumulation of multimorbidity and its influence on dementia risk: a UK Biobank study","year":2025,"lang":"en","type":"article","venue":"Brain Communications","topic":"Chronic Disease Management Strategies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020; Medical Research Council; European Commission; Academy of Medical Sciences; Horizon 2020 Framework Programme; Diabetes UK; Department of Health and Social Care; Canadian Institutes of Health Research; National Institute for Health and Care Research; Wellcome Trust; Alzheimer's Society; British Heart Foundation; Alzheimer's Association","keywords":"Dementia; Medicine; Multimorbidity; Biobank; Neurovascular bundle; Stroke (engine); Comorbidity; Depression (economics); Disease; Mental health; Risk factor; Diabetes mellitus; Anxiety; Psychiatry; Internal medicine; Bioinformatics; Surgery","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005066215,0.0005840921,0.0009650785,0.002161791,0.00128527,0.001751143,0.0009605509,0.001307054,0.002810453],"category_scores_gemma":[0.02315963,0.0008133755,0.0009508886,0.005566869,0.0006888811,0.001552225,0.00298248,0.001096491,0.0004746511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001974087,"about_ca_system_score_gemma":0.001041235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.08691072,"about_ca_topic_score_gemma":0.06792752,"domain_scores_codex":[0.9952186,0.002335863,0.0008582735,0.0008153637,0.0004280944,0.0003438905],"domain_scores_gemma":[0.9853309,0.003659449,0.005495674,0.002812226,0.001480906,0.001220842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001098181,0.0001426528,0.9870167,0.0001551164,0.0005158929,0.0004262129,0.003042338,0.0001320268,0.0002008125,0.0002699147,0.00204031,0.00495979],"study_design_scores_gemma":[0.00007524898,0.0001124873,0.9969823,0.0001092112,0.0001778466,0.000297255,0.0005442218,0.0002951558,0.00003109716,0.000118814,0.001226802,0.00002964005],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918429,0.001697333,0.0004771212,0.0004514892,0.00002907756,0.0001087671,0.004673221,0.000006838176,0.0007130515],"genre_scores_gemma":[0.9947389,0.0008472253,0.0007926866,0.000302858,0.00003586032,0.0002807206,0.002383587,0.000009113653,0.0006092101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08691072,"threshold_uncertainty_score":0.1728097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1083921389055578,"score_gpt":0.4343529160821338,"score_spread":0.325960777176576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}