{"id":"W4412487973","doi":"10.1002/jev2.70120","title":"Roadblocks of Urinary EV Biomarkers: Moving Toward the Clinic","year":2025,"lang":"en","type":"review","venue":"Journal of Extracellular Vesicles","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Alberta Oil Sands Technology and Research Authority","funders":"National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Instituto de Salud Carlos III; National Institutes of Health; Javna Agencija za Raziskovalno Dejavnost RS; European Regional Development Fund; European Commission; Kidney Foundation of Canada; Canadian Institutes of Health Research; American Diabetes Association; Queensland Health; H2020 European Research Council; Fundación Mutua Madrileña; Metro North Hospital and Health Service; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Comunidad de Madrid; Center for Cancer Research","keywords":"Status quo; Biomarker; Extracellular vesicles; Identification (biology); Computer science; Medicine; Engineering ethics; Risk analysis (engineering); Political science; Biology; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002631732,0.0006299647,0.001708325,0.000330093,0.0001091556,0.00006527414,0.001832434,0.0006735257,0.00009184411],"category_scores_gemma":[0.001107475,0.0004408435,0.002402863,0.0004172771,0.0003776717,0.00001692384,0.0003762865,0.0007397389,0.00001570529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005863484,"about_ca_system_score_gemma":0.001405148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003053522,"about_ca_topic_score_gemma":7.042523e-7,"domain_scores_codex":[0.9949039,0.001025124,0.002572519,0.0005049957,0.0005539154,0.0004394944],"domain_scores_gemma":[0.9946902,0.0004613061,0.003111935,0.001184901,0.0003433402,0.0002083566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002599893,0.0009014891,0.00005872855,0.01837722,0.002958592,0.0004859396,0.0001126339,0.00001580261,0.02373621,0.00005785751,0.009429853,0.9436057],"study_design_scores_gemma":[0.0005769511,0.0005944169,0.00001764597,0.01223113,0.002900088,0.0006866713,0.0002538418,0.000008421141,0.00707583,0.0001673893,0.9749177,0.0005699419],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001450568,0.9956392,0.001139354,0.00008741609,0.0006562605,0.0005451143,0.00005817655,0.00000850881,0.0004154124],"genre_scores_gemma":[0.003922791,0.9921402,0.001384266,0.00003381317,0.0008084563,0.00001620376,0.00005456483,0.00009049138,0.001549254],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9654878,"threshold_uncertainty_score":0.9998043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03253735724349199,"score_gpt":0.3293266438756345,"score_spread":0.2967892866321425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}