{"id":"W4412488983","doi":"10.1093/nar/gkaf666","title":"Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response","year":2025,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill; National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; School of Medicine, University of North Carolina at Chapel Hill; National Cancer Institute; National Institutes of Health; Fondation CHU de Québec; Université Laval; American Cancer Society","keywords":"Biology; PHD finger; Histone; Histone H3; RNA splicing; Chromatin; Genetics; Cell biology; DNA damage; Alternative splicing; DNA repair; Computational biology; RNA; Gene; DNA; Transcription factor; Zinc finger; Exon","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000115641,0.0001988869,0.0002123007,0.0001224218,0.0002398149,0.0002490299,0.0001622044,0.0002487414,0.001273199],"category_scores_gemma":[0.0001641432,0.0001143445,0.0002432173,0.0001189396,0.0001680006,0.0001906179,0.0002099485,0.0003014665,0.0006582745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003642954,"about_ca_system_score_gemma":0.0002305078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001284922,"about_ca_topic_score_gemma":0.001672638,"domain_scores_codex":[0.9998912,0.000008632855,0.000007913678,0.00003431734,0.00003487691,0.00002313729],"domain_scores_gemma":[0.9999138,0.000008872335,0.00002886394,0.000008930893,0.0000109952,0.00002861022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000532654,0.000005668626,0.0006454104,0.00002917874,0.000003430342,0.00006013778,0.00000622067,0.00006484937,0.9972143,0.00006285332,0.00007077141,0.001783958],"study_design_scores_gemma":[0.0000120693,0.00006622345,0.03786643,0.000007208934,0.00001126149,0.0007348174,0.00002908483,0.002186097,0.9536023,0.0001781395,0.005297016,0.000009524781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983323,0.002112611,0.0110609,0.0001977393,0.00003469246,0.00002369026,0.001379502,0.0002443587,0.001623449],"genre_scores_gemma":[0.9942398,0.0003015247,0.002940778,0.0000537147,0.000006811762,0.000009965867,0.0007793955,0.00002555172,0.001642428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001284922,"threshold_uncertainty_score":0.004259229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04209675808209809,"score_gpt":0.3468369828500817,"score_spread":0.3047402247679836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}