{"id":"W4412489184","doi":"10.1002/alz.70367","title":"Structural and functional connectivity in tau mutation carriers: from presymptomatic to symptomatic frontotemporal dementia","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Occupational Cancer Research Centre; Western University; McGill University; Sunnybrook Health Science Centre; McGill University Health Centre; University of Toronto; Montreal Neurological Institute and Hospital; Université Laval","funders":"NIHR Cambridge Biomedical Research Centre; UCLH Biomedical Research Centre; Medical Research Council; Instituto de Salud Carlos III; Fondation Philippe Chatrier; Tau Consortium; Canada First Research Excellence Fund; Association pour la Recherche sur la Sclérose Latérale Amyotrophique et autres Maladies du Motoneurone; Vetenskapsrådet; Fondation pour la Recherche sur Alzheimer; Ministero della Salute; Weston Brain Institute; Karolinska Institutet; ZonMw; Brain Research UK; McGill University; Deutsche Forschungsgemeinschaft; Brain Foundation; Wellcome Trust; University College London; Stichting Dioraphte; University of Cambridge; Canadian Institutes of Health Research; Fondation Vaincre Alzheimer; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Alzheimer Nederland; EU Joint Programme – Neurodegenerative Disease Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche","keywords":"Frontotemporal dementia; Mutation; Dementia; Functional connectivity; Medicine; Neuroscience; Psychology; Genetics; Internal medicine; Biology; Disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003000028,0.0004596195,0.0002699523,0.001268483,0.0004232327,0.0003856265,0.0001859351,0.0004088495,0.0017732],"category_scores_gemma":[0.00155322,0.0001592989,0.0002011441,0.0004895145,0.0003637435,0.0002987156,0.0003047757,0.0001815605,0.0001485841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002555015,"about_ca_system_score_gemma":0.0001644578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004785161,"about_ca_topic_score_gemma":0.007253367,"domain_scores_codex":[0.9998666,0.00001998394,0.00001597444,0.00005389987,0.00002179963,0.00002165962],"domain_scores_gemma":[0.9996225,0.00009189423,0.0001564413,0.00002400462,0.00003814492,0.00006704903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009611377,0.00008552192,0.985256,0.00002478349,0.0001121223,0.001766089,0.000685908,0.0001356152,0.005492043,0.00007258068,0.0001908972,0.005217394],"study_design_scores_gemma":[0.000006424812,0.0001053975,0.9983022,0.000003914882,0.00002398302,0.0009882352,0.0001368596,0.0001737291,0.0001318241,0.00007970521,0.00004502503,0.000002762355],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997483,0.00004453697,0.00003218391,0.000007115166,9.814448e-7,0.000002615382,0.00007881169,0.000001530124,0.0000840026],"genre_scores_gemma":[0.9997281,0.00002170252,0.00005636189,0.000003444359,0.000001963139,0.000003468581,0.0001261,0.000001062916,0.00005779551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004785161,"threshold_uncertainty_score":0.00951457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02673008765625876,"score_gpt":0.2939134596961287,"score_spread":0.26718337203987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}