{"id":"W4412489427","doi":"10.1002/advs.202507167","title":"PLAUR <sup>+</sup> Neutrophils Drive Anti‐PD‐1 Therapy Resistance in Patients with Hepatocellular Carcinoma by Shaping an Immunosuppressive Microenvironment","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Natural Science Foundation of China","keywords":"Immunotherapy; Tumor microenvironment; Immune system; Cancer research; Immunology; Biology; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002617869,0.0003471724,0.0003922514,0.0002402888,0.0005450777,0.00004601766,0.001088679,0.0001389555,0.0001040938],"category_scores_gemma":[0.00003304748,0.0003048047,0.000048016,0.0007267622,0.00162498,0.000730756,0.0002078917,0.0004415175,0.00003441746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003327655,"about_ca_system_score_gemma":0.000204182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005770223,"about_ca_topic_score_gemma":0.000009974858,"domain_scores_codex":[0.9973861,0.0001560718,0.0004113139,0.001024404,0.0001580328,0.0008641035],"domain_scores_gemma":[0.9986505,0.00008220614,0.0001993817,0.0009110394,0.000118738,0.0000381695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007586154,0.0003199691,0.23687,0.00001518227,0.00003135285,0.000009177183,0.001225734,0.0008953081,0.7577532,0.0001536496,0.000208986,0.001758833],"study_design_scores_gemma":[0.005533285,0.0003686222,0.3011563,0.0002194043,0.00001273321,0.000001840413,0.0004374232,0.00006368796,0.6808546,0.0001302123,0.01074137,0.0004805415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855033,0.01266279,0.0001968621,0.0001155592,0.0003379646,0.0007555389,0.0000445145,0.00004253527,0.0003409222],"genre_scores_gemma":[0.9973974,0.0003850702,0.0006823985,0.0004526954,0.000005697822,0.0001219787,0.00006795611,0.00002481255,0.0008620475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07689866,"threshold_uncertainty_score":0.9999404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005539512579706475,"score_gpt":0.2141708916893425,"score_spread":0.208631379109636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}