{"id":"W4412490691","doi":"10.1021/jacs.5c08176","title":"An Expedient Synthesis of the Antimitotic Natural Products Sarcodictyin and Eleutherobin, and Carbohydrate Analogues","year":2025,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC","keywords":"Chemistry; Carbohydrate; Natural (archaeology); Antimitotic Agent; Combinatorial chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144625,0.0003097027,0.0001359024,0.000230208,0.0001812383,0.0001587093,0.0001970335,0.0002035542,0.001169174],"category_scores_gemma":[0.0001248106,0.00008568852,0.0001173101,0.00033037,0.0001341615,0.0003006597,0.0003113692,0.0003785388,0.0004316002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001740738,"about_ca_system_score_gemma":0.0005011294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005550496,"about_ca_topic_score_gemma":0.001923301,"domain_scores_codex":[0.9999423,0.000007977134,0.000006869667,0.00001242358,0.00001320054,0.00001709404],"domain_scores_gemma":[0.9999717,0.000003361714,0.000006891241,0.000005004823,0.000005498962,0.000007444162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001213771,0.0002189522,0.0003544305,0.000618508,0.00003591493,0.0009905613,0.0003677999,0.003761477,0.929518,0.007340801,0.001076169,0.05559609],"study_design_scores_gemma":[0.00007712082,0.001256673,0.001872904,0.00006455158,0.00005194205,0.0009192639,0.0001598836,0.002446597,0.9276999,0.001890728,0.063515,0.00004551357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8819783,0.008797402,0.06403229,0.0005999842,0.0002389198,0.0005394873,0.001354729,0.0002445513,0.04221445],"genre_scores_gemma":[0.9549542,0.007509104,0.02725658,0.0001775258,0.00003307278,0.0001452126,0.0005154065,0.00003714049,0.009371652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001169174,"threshold_uncertainty_score":0.003911257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005484282634806992,"score_gpt":0.2256526068144223,"score_spread":0.2201683241796153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}