{"id":"W4412490857","doi":"10.1139/bcb-2025-0125","title":"Zyxin directly binds to chromosomal DNA and is linked with mitochondrial integrity and apoptosis","year":2025,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Photosynthetic Processes and Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary; University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Biology; Cell biology; Gene knockdown; LIM domain; Nuclear localization sequence; Transcription factor; Molecular biology; Genetics; Gene; Cytoplasm; Zinc finger","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000800467,0.0002073731,0.0002238159,0.0002491494,0.0002235943,0.0003270089,0.0001159993,0.0002508455,0.001103373],"category_scores_gemma":[0.0001547733,0.0001390891,0.0001894483,0.0002670978,0.0001625688,0.0001381844,0.0003096951,0.0003406306,0.0002429383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000295939,"about_ca_system_score_gemma":0.0001536605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007657434,"about_ca_topic_score_gemma":0.00116721,"domain_scores_codex":[0.9998407,0.00001365219,0.00001107275,0.00005125548,0.00005034294,0.00003290879],"domain_scores_gemma":[0.9998754,0.00001445281,0.00006409035,0.000008826556,0.0000159068,0.00002126059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009334402,0.000007947206,0.002730351,0.00007025471,0.00001344098,0.00007941519,0.00001692515,0.00005407255,0.9950162,0.00008443841,0.00006070809,0.001772983],"study_design_scores_gemma":[0.00001803036,0.0001476822,0.1438655,0.00002449206,0.00005317249,0.0008827734,0.0001205148,0.001487287,0.8479165,0.0001908152,0.005283702,0.000009656851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890547,0.004309464,0.004892851,0.00009201311,0.0000229737,0.00001437346,0.0006196181,0.00006227606,0.000931692],"genre_scores_gemma":[0.9950173,0.0009290576,0.001100804,0.00005767725,0.000004405441,0.00001163441,0.0007370019,0.000009391896,0.002132658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001103373,"threshold_uncertainty_score":0.003691137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005055305482017154,"score_gpt":0.2260272750975432,"score_spread":0.2209719696155261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}