{"id":"W4412492204","doi":"10.1038/s41577-025-01213-x","title":"BRD4 acts as a pH sensor to tune inflammation","year":2025,"lang":"en","type":"review","venue":"Nature reviews. Immunology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Disability Prevention and Rehabilitation; University of Toronto","funders":"","keywords":"Inflammation; Chemistry; Nanotechnology; Medicine; Materials science; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0006182229,0.000710263,0.004984529,0.001151155,0.00009617326,0.00003259291,0.0003143908,0.002102758,0.0009443289],"category_scores_gemma":[0.003293518,0.0005161485,0.001697239,0.001906142,0.00006805962,0.00006303437,0.0001771572,0.002608085,0.005046445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003393109,"about_ca_system_score_gemma":0.0006822686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008231033,"about_ca_topic_score_gemma":0.000009253167,"domain_scores_codex":[0.9963017,0.0006770687,0.001520081,0.0007586598,0.0002742113,0.0004683379],"domain_scores_gemma":[0.9974321,0.0002548455,0.0007111318,0.001142917,0.0002815679,0.0001774116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001976087,0.00005065429,2.062438e-7,0.03053511,0.0005390606,0.00009290137,0.00002062767,2.827183e-8,0.000126352,0.0006523282,0.009547227,0.9584157],"study_design_scores_gemma":[0.000305626,0.00009683493,0.000002329119,0.1278126,0.001939819,0.0004148452,0.000005875799,2.245968e-7,0.00004408958,0.00001889266,0.8690328,0.0003260342],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000033862,0.9833421,0.00003514243,0.002043116,0.000286395,0.002498474,0.00003708088,0.0001266384,0.01162765],"genre_scores_gemma":[0.000002404707,0.9752578,0.0005521331,0.00273164,0.0005147699,0.0003752978,0.001169546,0.00004941822,0.01934703],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9580897,"threshold_uncertainty_score":0.9999689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02257992820098061,"score_gpt":0.3891542286013648,"score_spread":0.3665743004003842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}