{"id":"W4412492661","doi":"10.1093/bjd/ljaf280","title":"Mendelian randomization identifies OX40 as a potential mediator of the effects of cigarette smoking on palmoplantar pustulosis","year":2025,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Norwegian Institute of Public Health; Faculty of Medicine and Health, University of Sydney; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Sun Pharma; Astellas Pharma; Helse Midt-Norge; National Institute for Health and Care Research; Norges Teknisk-Naturvitenskapelige Universitet; Medical Research Council; Celgene; Biogen; China Scholarship Council; Leading Edge Endowment Fund; Sanofi; Amgen; Pfizer; King's College London; Galderma; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Mendelian randomization; Palmoplantar pustulosis; Mediator; Medicine; Randomization; Cigarette smoking; Dermatology; Internal medicine; Clinical trial; Immunology; Psoriasis; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490008,0.00008521141,0.0005033351,0.0002379443,0.00007731198,0.000014721,0.0001274999,0.00009828849,0.00005706602],"category_scores_gemma":[0.0009929277,0.00007118172,0.0002815096,0.0001904122,0.00009119503,0.00006595063,0.00003303654,0.0003070121,6.145875e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002755912,"about_ca_system_score_gemma":0.0001466404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000659955,"about_ca_topic_score_gemma":0.00001656782,"domain_scores_codex":[0.9986753,0.0001694635,0.0006764567,0.00009019823,0.0002698674,0.0001187504],"domain_scores_gemma":[0.9986824,0.0002976813,0.0005483016,0.0001147128,0.0003129803,0.0000439069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006678971,0.001560717,0.05074884,0.002945369,0.004882249,0.006283246,0.001439859,0.0002492612,0.8367013,0.0008836084,0.06902738,0.01859914],"study_design_scores_gemma":[0.009469998,0.0002052322,0.01677381,0.004654663,0.0008290467,0.02384042,0.0002836309,0.00008229927,0.9429737,0.00035179,0.0004613019,0.00007416453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939858,0.001518165,0.0005440227,0.001608223,0.00178776,0.0001945572,0.00001092261,0.000005825381,0.000344667],"genre_scores_gemma":[0.9989464,0.0005357389,0.00002440688,0.0003467069,0.00007710949,0.000003590925,0.000004509898,0.000008518284,0.00005296827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1062723,"threshold_uncertainty_score":0.2902706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003880486165490858,"score_gpt":0.2415474780635899,"score_spread":0.2376669918980991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}