{"id":"W4412492661","doi":"10.1093/bjd/ljaf280","title":"Mendelian randomization identifies OX40 as a potential mediator of the effects of cigarette smoking on palmoplantar pustulosis","year":2025,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Norwegian Institute of Public Health; Faculty of Medicine and Health, University of Sydney; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Sun Pharma; Astellas Pharma; Helse Midt-Norge; National Institute for Health and Care Research; Norges Teknisk-Naturvitenskapelige Universitet; Medical Research Council; Celgene; Biogen; China Scholarship Council; Leading Edge Endowment Fund; Sanofi; Amgen; Pfizer; King's College London; Galderma; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Mendelian randomization; Palmoplantar pustulosis; Mediator; Medicine; Randomization; Cigarette smoking; Dermatology; Internal medicine; Clinical trial; Immunology; Psoriasis; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01887706,0.001222384,0.002247877,0.001269973,0.0006192535,0.0009578738,0.001306789,0.001898254,0.005964765],"category_scores_gemma":[0.02768573,0.0005808367,0.002074173,0.001241763,0.001142332,0.0005753962,0.001014641,0.001311073,0.0002933933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005780713,"about_ca_system_score_gemma":0.001244209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001492419,"about_ca_topic_score_gemma":0.001291876,"domain_scores_codex":[0.9743114,0.01809073,0.0009438175,0.003305389,0.002216805,0.001131825],"domain_scores_gemma":[0.982506,0.0125452,0.001437307,0.002921118,0.0003589558,0.00023137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.07851351,0.002507955,0.3369572,0.003328721,0.02208281,0.02012935,0.003071879,0.02237267,0.1332461,0.1652862,0.007900029,0.2046036],"study_design_scores_gemma":[0.018908,0.02923471,0.4029795,0.0005562791,0.02172258,0.02377119,0.000914274,0.278467,0.04916866,0.1387064,0.03491698,0.0006544642],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7597282,0.001587283,0.2284368,0.001109807,0.0003649415,0.002724615,0.00193701,0.0007376603,0.003373733],"genre_scores_gemma":[0.902248,0.0004104186,0.09085938,0.0005604243,0.00006732598,0.002486577,0.0004065873,0.0001057122,0.002855579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01887706,"threshold_uncertainty_score":0.09983265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003880486165490858,"score_gpt":0.2415474780635899,"score_spread":0.2376669918980991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}