{"id":"W4412492930","doi":"10.1093/brain/awaf251","title":"CSF proteomic profiles related to cognitive decline in MCI A+ depend on tau levels","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; IXICO; H. Lundbeck A/S; ZonMw; Amsterdam Neuroscience; Genentech; Norges Forskningsråd; Eisai; Meso Scale Diagnostics; Bentham-Moxon Trust; Servier; BioClinica; Biogen; Pfizer; Alzheimer Nederland; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Disease Neuroimaging Initiative; Universitetet i Bergen; Northern California Institute for Research and Education; Novartis Pharmaceuticals Corporation; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association","keywords":"Dementia; Cognitive decline; Biomarker; Psychology; Oncology; Neuroimaging; Cognition; Cerebrospinal fluid; Cohort; Internal medicine; Proportional hazards model; Amyloid (mycology); Neuroscience; Alzheimer's Disease Neuroimaging Initiative; Disease; Neuropsychology; Medicine; Pathology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003501579,0.0002915279,0.0002631242,0.0008301238,0.0002884389,0.0005567194,0.0001535277,0.0002943259,0.0005858101],"category_scores_gemma":[0.000999485,0.0001773363,0.0001918713,0.000450217,0.0002994242,0.0002464755,0.0003315317,0.0002577718,0.000148079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001926484,"about_ca_system_score_gemma":0.0001351927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003289235,"about_ca_topic_score_gemma":0.003071362,"domain_scores_codex":[0.999838,0.00002137109,0.00002491762,0.00004912921,0.00003972156,0.00002682333],"domain_scores_gemma":[0.9996865,0.00004686852,0.0001433266,0.00002874235,0.0000501341,0.00004437368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001583771,0.0001125707,0.8853607,0.00005195482,0.0001791859,0.0005511239,0.0006109783,0.0001786357,0.1005566,0.00007464497,0.0002188198,0.01052093],"study_design_scores_gemma":[0.000004869027,0.0001200308,0.9976739,0.000002510609,0.0000178835,0.0003574557,0.0001097793,0.0001154243,0.001492663,0.00003622855,0.00006534118,0.000003948673],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996125,0.0001170215,0.00006225841,0.000007822239,0.000001558514,0.000002105914,0.00007670369,0.0000029679,0.000117139],"genre_scores_gemma":[0.9993399,0.00009153976,0.0001662125,0.00002361992,0.000005542727,0.000006012994,0.0002106064,0.000002286994,0.0001542979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003289235,"threshold_uncertainty_score":0.006540179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03235998110839196,"score_gpt":0.3717062172242732,"score_spread":0.3393462361158812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}