{"id":"W4412492978","doi":"10.1371/journal.pone.0328256","title":"ATP synthase inhibition, an overlooked confounding factor in the mitochondrial stress test","year":2025,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Extracellular; Respiration; Glycolysis; ATP synthase; Mitochondrion; Metabolism; Biology; Chemistry; Biochemistry; Enzyme; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002289829,0.001211674,0.001112022,0.0004429047,0.0005594192,0.0007512477,0.000979639,0.0009835267,0.001066429],"category_scores_gemma":[0.003012375,0.0004438459,0.0006556947,0.0005868319,0.0009691067,0.0006855463,0.0009194486,0.001885603,0.0003983564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005186331,"about_ca_system_score_gemma":0.0006719051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001083535,"about_ca_topic_score_gemma":0.001909166,"domain_scores_codex":[0.9961132,0.001171747,0.0004120037,0.000719226,0.001301044,0.0002826119],"domain_scores_gemma":[0.9970075,0.001142857,0.0005843172,0.0004229665,0.0006820375,0.0001602597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006949313,0.00007167429,0.003906344,0.0004476611,0.00005828412,0.0002816857,0.0001546853,0.0002465535,0.9883085,0.0003847879,0.0001786481,0.005266115],"study_design_scores_gemma":[0.00002274793,0.001325945,0.008977531,0.00005309378,0.000117493,0.0004082955,0.0001169556,0.00163961,0.9816332,0.0005091431,0.005166468,0.00002954968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8162806,0.01868738,0.1529268,0.002101295,0.001965696,0.0007498798,0.001592913,0.0005832867,0.00511211],"genre_scores_gemma":[0.9393655,0.005007259,0.04807661,0.001084549,0.0002363108,0.0009570202,0.001409438,0.000180716,0.003682756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002289829,"threshold_uncertainty_score":0.01210994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02854041553773183,"score_gpt":0.2642747393927367,"score_spread":0.2357343238550049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}