{"id":"W4412493495","doi":"10.1182/bloodadvances.2025016651","title":"High-grade B-cell lymphoma, not otherwise specified: an LLMPP study","year":2025,"lang":"en","type":"article","venue":"Blood Advances","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency; Simon Fraser University; University of Toronto; University Health Network; Spinal Cord Injury BC; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Genome British Columbia; National Cancer Institute; Genome Canada","keywords":"Diffuse large B-cell lymphoma; Lymphoma; Not Otherwise Specified; Cell of origin; Biology; Germinal center; Population; Cancer research; Oncology; Pathology; Medicine; B cell; Internal medicine; Cancer; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000936763,0.0002570117,0.0004405919,0.0001268173,0.00012404,0.00004114639,0.0001521681,0.00005793324,0.0001008186],"category_scores_gemma":[0.0000200279,0.0001938007,0.0001020035,0.0002816988,0.00005431069,0.0001683715,0.00004686075,0.00004841813,0.00008518625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008387579,"about_ca_system_score_gemma":0.0001108594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002582108,"about_ca_topic_score_gemma":0.0002424739,"domain_scores_codex":[0.9985558,0.00005408333,0.0002998509,0.0005064096,0.0002876185,0.0002961846],"domain_scores_gemma":[0.9990423,0.00009710329,0.00008260417,0.0005783401,0.0000520191,0.0001476881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009062964,0.1030757,0.7328844,0.0002394914,0.0009431432,0.001417857,0.001081233,0.00003440594,0.003237218,0.004154979,0.001708337,0.1503169],"study_design_scores_gemma":[0.04146462,0.00296856,0.7219707,0.0001388729,0.001362401,0.00002789392,0.002308895,0.00001035871,0.1535996,0.0004590702,0.07529644,0.0003925903],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829217,0.005427716,0.000008680364,0.0006198233,0.000401265,0.0008210145,0.00001862326,0.0001405801,0.009640635],"genre_scores_gemma":[0.9930157,0.0006106018,0.001482255,0.0008533538,0.0002246354,0.0001633571,0.00001889064,0.00002369951,0.003607506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1503624,"threshold_uncertainty_score":0.7902963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01410312446159241,"score_gpt":0.2886159136219906,"score_spread":0.2745127891603982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}