{"id":"W4412493725","doi":"10.1021/acsinfecdis.5c00351","title":"Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity","year":2025,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; Structural Genomics Consortium","funders":"Genentech; Center for Scientific Review; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; National Institutes of Health; Ontario Genomics; Genome Canada; McGill University; North Carolina Biotechnology Center; National Institute of Allergy and Infectious Diseases; Bayer; Bristol-Myers Squibb; Pfizer; National Science Foundation","keywords":"Helicase; RNA Helicase A; Alphavirus; Biology; RNA; Allosteric regulation; Chikungunya; Enantiomer; Viral replication; RNA-dependent RNA polymerase; Virology; Virus; Chemistry; Stereochemistry; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005525847,0.0002897558,0.0004661019,0.0001359199,0.0002057056,0.00006160507,0.00009699717,0.0001028021,0.00004817813],"category_scores_gemma":[0.0003338879,0.0002249167,0.0002686666,0.0003868016,0.0001357976,0.0001407898,0.00004983462,0.0001650872,0.00000988211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001341772,"about_ca_system_score_gemma":0.0005276792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007666255,"about_ca_topic_score_gemma":0.00002597112,"domain_scores_codex":[0.9985592,0.00003895008,0.0001985553,0.0005499444,0.0002127232,0.0004405951],"domain_scores_gemma":[0.9988134,0.0001547978,0.00009511494,0.0004072034,0.0002762701,0.0002532116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02019996,0.01217795,0.6571704,0.002228189,0.003207864,0.000278547,0.0001412333,0.00002344235,0.136282,0.01166414,0.01085971,0.1457666],"study_design_scores_gemma":[0.04834792,0.006272064,0.7269876,0.001349728,0.0126014,0.0002663079,0.0001826158,0.001761553,0.1781371,0.006711687,0.01534751,0.002034504],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865811,0.0007499924,0.007227024,0.0006444224,0.0001591689,0.002075638,0.0001907706,0.0003598747,0.00201204],"genre_scores_gemma":[0.997086,0.00003291362,0.00006234664,0.001029167,0.0003201347,0.0007949647,0.00008434761,0.000037343,0.0005527852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1437321,"threshold_uncertainty_score":0.9171839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004808226312289755,"score_gpt":0.2745753695231437,"score_spread":0.2697671432108539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}