{"id":"W4412493725","doi":"10.1021/acsinfecdis.5c00351","title":"Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity","year":2025,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; Structural Genomics Consortium","funders":"Genentech; Center for Scientific Review; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; National Institutes of Health; Ontario Genomics; Genome Canada; McGill University; North Carolina Biotechnology Center; National Institute of Allergy and Infectious Diseases; Bayer; Bristol-Myers Squibb; Pfizer; National Science Foundation","keywords":"Helicase; RNA Helicase A; Alphavirus; Biology; RNA; Allosteric regulation; Chikungunya; Enantiomer; Viral replication; RNA-dependent RNA polymerase; Virology; Virus; Chemistry; Stereochemistry; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002162657,0.0003597672,0.0001540963,0.0001064011,0.0001495859,0.0001840931,0.0002556169,0.0003193649,0.002022341],"category_scores_gemma":[0.0001583666,0.0001434701,0.0001667946,0.0001068359,0.0001679608,0.0001720675,0.0001654727,0.0004505839,0.0004225181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002082049,"about_ca_system_score_gemma":0.0001737718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004643223,"about_ca_topic_score_gemma":0.0008220455,"domain_scores_codex":[0.9998846,0.00002241996,0.000006015875,0.00002827532,0.00003036862,0.00002839048],"domain_scores_gemma":[0.9999392,0.00001197482,0.00001663789,0.000009817732,0.00001121944,0.00001108346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008465826,0.00002179269,0.00007121561,0.00002927855,0.000004299146,0.00004364871,0.00001340155,0.00009780929,0.9977181,0.0001800818,0.00006369319,0.001672086],"study_design_scores_gemma":[0.00001318023,0.0001942206,0.0003041216,0.000001815559,0.000004050235,0.00009393187,0.000008244641,0.0004728239,0.9977108,0.0000196044,0.001173579,0.000003542613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759772,0.001200232,0.0118851,0.0002094178,0.00004051862,0.00008880365,0.0004239625,0.0001501875,0.01002468],"genre_scores_gemma":[0.9823485,0.001314213,0.01065162,0.0001644275,0.00001731525,0.00006121065,0.0004947428,0.00003726703,0.004910522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002022341,"threshold_uncertainty_score":0.006765425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004808226312289755,"score_gpt":0.2745753695231437,"score_spread":0.2697671432108539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}