{"id":"W4412493946","doi":"10.14814/phy2.70463","title":"Preclinical assessment of the selective androgen receptor modulator <scp>RAD140</scp> to increase muscle mass and bone mineral density","year":2025,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Lakehead University","funders":"Northern Ontario Academic Medicine Association","keywords":"Muscle hypertrophy; Internal medicine; Endocrinology; Bone mineral; Medicine; Androgen receptor; Skeletal muscle; Receptor; Motor coordination; Chemistry; Osteoporosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002795622,0.0001780133,0.0003162805,0.00002390218,0.0001156233,0.00000804799,0.0001267608,0.0002230597,0.000007376867],"category_scores_gemma":[0.001306015,0.0001207961,0.0001549825,0.000150685,0.0002140311,0.000004253932,0.0003612456,0.0001620148,7.905963e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001444385,"about_ca_system_score_gemma":0.0001243439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003234246,"about_ca_topic_score_gemma":0.000009233547,"domain_scores_codex":[0.9984667,0.000209508,0.0003715571,0.000592237,0.0001152366,0.0002448182],"domain_scores_gemma":[0.9990259,0.00009785854,0.0001781063,0.0004627847,0.000119413,0.0001159135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006412581,0.0001999486,0.0452832,0.00001964122,0.00007624299,0.000004578425,0.00001229336,0.0001471154,0.9490317,0.0001493648,0.004432212,0.0005795721],"study_design_scores_gemma":[0.0003104044,0.0004462617,0.9231131,0.0000170572,0.00003590025,0.000008093521,0.0000302522,0.00009011141,0.07013862,0.003322205,0.002400855,0.00008714649],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977428,0.0001645043,0.0002059604,0.0001190588,0.0001619994,0.0003909002,0.00001115631,0.000013787,0.001189817],"genre_scores_gemma":[0.9980574,0.00003772801,0.0006850309,0.0007553743,0.00007217802,0.00005512188,0.00004150166,0.000007552251,0.0002881185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8788931,"threshold_uncertainty_score":0.4925922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209954857507681,"score_gpt":0.2937925743863369,"score_spread":0.2816930258112601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}