{"id":"W4412496444","doi":"10.1245/s10434-025-17903-8","title":"Concerns Regarding Study Selection and Methodological Rigor in Meta-Analysis on Neoadjuvant Chemotherapy for Colon Cancer","year":2025,"lang":"en","type":"letter","venue":"Annals of Surgical Oncology","topic":"Colorectal Cancer Surgical Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Surgical oncology; Medicine; Neoadjuvant therapy; Meta-analysis; Colorectal cancer; Oncology; Chemotherapy; Selection (genetic algorithm); Internal medicine; General surgery; Cancer; Breast cancer; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.3959251,0.001112954,0.004452928,0.004799454,0.003409658,0.008224519,0.004142153,0.02354626,0.004139559],"category_scores_gemma":[0.7816653,0.002158049,0.005505761,0.00602202,0.008248208,0.005634955,0.003450074,0.01671849,0.002067293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006140038,"about_ca_system_score_gemma":0.01103777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005804221,"about_ca_topic_score_gemma":0.01314878,"domain_scores_codex":[0.4186388,0.4717816,0.06740396,0.00877033,0.0308111,0.002594184],"domain_scores_gemma":[0.1117279,0.8253728,0.02194461,0.01383186,0.02448435,0.00263852],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003687646,0.0001323499,0.03709602,0.01215393,0.01589418,0.003863221,0.004475,0.001345233,0.0006151048,0.03667232,0.6772929,0.206772],"study_design_scores_gemma":[0.007744388,0.001119058,0.02719885,0.04185599,0.02220698,0.01075513,0.003026482,0.01224084,0.00242289,0.2994837,0.5709864,0.0009593043],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003613766,0.02076899,0.006391957,0.9342425,0.02741521,0.0003300847,0.0007129571,0.0001041059,0.006420305],"genre_scores_gemma":[0.06105736,0.005842798,0.01840389,0.8563014,0.05498345,0.00148493,0.000167446,0.0001582151,0.001600563],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.6040749,"threshold_uncertainty_score":0.7449319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4272168377082393,"score_gpt":0.530307477059196,"score_spread":0.1030906393509567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}