{"id":"W4412501876","doi":"10.1101/2025.07.18.665585","title":"SUZ12–Nucleic Acid Interactions Constrain PRC2 Activity to Maintain Targeted Gene Silencing Essential to Diffuse Midline Glioma","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University Health Centre; McGill University","funders":"National Institutes of Health; Otto A. Malm Lahjoitusrahasto; Alex's Lemonade Stand Foundation for Childhood Cancer; Sigrid Juséliuksen Säätiö; Emil Aaltosen Säätiö; Rally Foundation; University of Wisconsin Carbone Cancer Center","keywords":"Gene silencing; Nucleic acid; PRC2; Glioma; Gene; Cell biology; Cancer research; Biology; Chemistry; Genetics; Epigenetics; EZH2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162837,0.0003030606,0.0001734517,0.0001160262,0.0001721088,0.0002614574,0.000258574,0.0001547128,0.0006967132],"category_scores_gemma":[0.0001544317,0.0001607342,0.0001641261,0.00008861595,0.00027913,0.0001627229,0.0002823615,0.0003372604,0.0003148333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003979712,"about_ca_system_score_gemma":0.0002465914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008711668,"about_ca_topic_score_gemma":0.001964386,"domain_scores_codex":[0.9998732,0.0000233376,0.00001447778,0.00002823576,0.00003330627,0.00002761718],"domain_scores_gemma":[0.9998608,0.00002065199,0.00004619339,0.00002084436,0.00001463493,0.00003679447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003502421,0.000003971631,0.0001152051,0.000008220713,0.000001493619,0.00001495545,0.000005497765,0.0001006318,0.999328,0.0001138428,0.000006058279,0.0002670662],"study_design_scores_gemma":[0.000005206547,0.00004981337,0.002448821,0.000002349446,0.000004828968,0.0001092807,0.00001842847,0.00218179,0.9939222,0.00004927728,0.001204256,0.000003725692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942345,0.0004013893,0.004658081,0.00002983571,0.000007499519,0.000007985648,0.00009118795,0.00004697586,0.0005225793],"genre_scores_gemma":[0.9974326,0.00009068095,0.00161643,0.000008925298,0.000002150384,0.00000758255,0.00009767151,0.00001162115,0.0007323621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008711668,"threshold_uncertainty_score":0.002887428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01278286820621439,"score_gpt":0.2585484658862715,"score_spread":0.2457655976800571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}