{"id":"W4412502273","doi":"10.1101/2025.07.16.665070","title":"Self-limiting population suppression gene drive in the West Nile vector mosquito, <i>Culex quinquefasciatus</i>","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Shenzhen Bay Laboratory; Zhejiang University; National Natural Science Foundation of China","keywords":"Culex quinquefasciatus; Vector (molecular biology); Limiting; Biology; Culex; Gene; West Nile virus; Population; Virology; Genetics; Ecology; Larva; Engineering; Medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000119941,0.0001672891,0.0000780351,0.00008371857,0.00007890324,0.0001721254,0.0001833119,0.0001082144,0.0009312411],"category_scores_gemma":[0.0000586762,0.00006628902,0.0001062199,0.00004091802,0.0001157667,0.00009580303,0.0001190484,0.000192599,0.0002092046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002148175,"about_ca_system_score_gemma":0.0001053233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009433432,"about_ca_topic_score_gemma":0.001621734,"domain_scores_codex":[0.9999548,0.000006216073,0.000003013178,0.00001476952,0.00001407552,0.000007128489],"domain_scores_gemma":[0.9999713,0.000004532264,0.00001169507,0.000003783036,0.000003522077,0.000005152716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002662066,0.0000187857,0.0005840078,0.00003466076,0.000007317917,0.00007115075,0.000018118,0.00059094,0.9939862,0.0006596044,0.0002462526,0.003756172],"study_design_scores_gemma":[0.00002630285,0.0001857011,0.004335192,0.000007532802,0.00001666788,0.0002491352,0.00003464686,0.01441884,0.9715768,0.000223308,0.008916444,0.000009555795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767636,0.0003722161,0.01792506,0.0001087829,0.00003079978,0.00003275919,0.0004713426,0.0003184611,0.003976962],"genre_scores_gemma":[0.9870025,0.0002244992,0.006941396,0.00004590941,0.000003883762,0.00001931556,0.0004111227,0.00004389112,0.005307553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009433432,"threshold_uncertainty_score":0.003115296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007091926286254703,"score_gpt":0.2236399555920257,"score_spread":0.216548029305771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}