{"id":"W4412502273","doi":"10.1101/2025.07.16.665070","title":"Self-limiting population suppression gene drive in the West Nile vector mosquito, <i>Culex quinquefasciatus</i>","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Shenzhen Bay Laboratory; Zhejiang University; National Natural Science Foundation of China","keywords":"Culex quinquefasciatus; Vector (molecular biology); Limiting; Biology; Culex; Gene; West Nile virus; Population; Virology; Genetics; Ecology; Larva; Engineering; Medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005978308,0.000523949,0.0004027839,0.0001559434,0.0002305476,0.0001758902,0.0008207181,0.0008253697,0.000009565346],"category_scores_gemma":[0.0001666621,0.0004845677,0.0001921954,0.0003707364,0.00006148872,0.00001051128,0.0005748101,0.0006308756,0.00001018986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462927,"about_ca_system_score_gemma":0.0004541627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001144318,"about_ca_topic_score_gemma":0.0001000797,"domain_scores_codex":[0.9971282,0.0003149769,0.0005579103,0.001028455,0.0003768569,0.000593606],"domain_scores_gemma":[0.9977991,0.00004009766,0.0003515554,0.001427809,0.0002830749,0.00009836553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005347708,0.0001774874,0.02199473,0.0003622739,0.00009104166,0.00002369841,0.00003816271,0.0003581063,0.9756581,0.0001371032,0.001102368,0.000003497862],"study_design_scores_gemma":[0.0005328323,0.00008330908,0.2151783,0.0003218011,0.0001105956,4.543553e-8,0.00001313494,0.00023387,0.7705557,0.000003688591,0.01225559,0.0007111326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994808,0.002384235,0.000286243,0.0001901517,0.001051379,0.0008485783,0.0002781963,0.00008784304,0.00006536673],"genre_scores_gemma":[0.9936929,0.0009746877,0.003426828,0.0005629061,0.001016651,0.0002275713,0.00001773111,0.00006449815,0.00001625405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2051023,"threshold_uncertainty_score":0.9997606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007091926286254703,"score_gpt":0.2236399555920257,"score_spread":0.216548029305771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}