{"id":"W4412519569","doi":"10.1111/ahg.70013","title":"Inherited Susceptibility to Cancer: Past, Present and Future","year":2025,"lang":"en","type":"review","venue":"Annals of Human Genetics","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; McGill University","funders":"NIHR Cambridge Biomedical Research Centre; National Institute for Health and Care Research; Department of Health and Social Care; Cancer Research UK","keywords":"Cancer; Genetics; Biology; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000197848,0.0004548224,0.001839218,0.0002641511,0.00005994398,0.00001900435,0.0002715052,0.0004089726,0.0002723494],"category_scores_gemma":[0.00002636339,0.000385786,0.0003438615,0.0004276754,0.0001441897,0.000009570007,0.000322764,0.0003538939,0.000004578534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000614859,"about_ca_system_score_gemma":0.0004895236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006092573,"about_ca_topic_score_gemma":0.00008065652,"domain_scores_codex":[0.9977449,0.0001246404,0.0007672433,0.0006254401,0.0003773758,0.0003604268],"domain_scores_gemma":[0.9981291,0.00009060957,0.0002542191,0.0008509175,0.0004053849,0.000269795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002445038,0.00008570006,0.0003712134,0.03419035,0.0002605567,0.00000528592,0.0001308452,0.00000138097,0.00002699344,0.000006126233,0.05696654,0.9079306],"study_design_scores_gemma":[0.0001716712,0.0007613199,0.001583605,0.007812548,0.0007062193,0.000005845526,0.00002445327,6.470185e-7,0.0001872023,0.00004709845,0.9884187,0.0002806825],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004324959,0.9912156,0.000001586335,0.001231673,0.0004153915,0.001846499,0.0002031834,0.00002842577,0.0007326123],"genre_scores_gemma":[0.0001758956,0.9953328,0.0003188248,0.0003662355,0.002135081,0.0001656877,0.00006761948,0.00005236681,0.001385516],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9314522,"threshold_uncertainty_score":0.9998594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1287659860064496,"score_gpt":0.4477592162618068,"score_spread":0.3189932302553572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}