{"id":"W4412520481","doi":"10.1016/s2213-2600(25)00194-8","title":"Bedaquiline, delamanid, linezolid, and clofazimine for rifampicin-resistant and fluoroquinolone-resistant tuberculosis (endTB-Q): an open-label, multicentre, stratified, non-inferiority, randomised, controlled, phase 3 trial","year":2025,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Unitaid; National Institutes of Health; Fonds Wetenschappelijk Onderzoek; Médecins Sans Frontières; Wellcome Trust; Maryland State Fair; National Institute of Allergy and Infectious Diseases","keywords":"Medicine; Clofazimine; Bedaquiline; Rifampicin; Linezolid; Tuberculosis; Internal medicine; Moxifloxacin; Antibiotics; Mycobacterium tuberculosis; Microbiology; Vancomycin; Staphylococcus aureus; Dermatology; Leprosy; Bacteria; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003998647,0.001466976,0.002749404,0.0003976167,0.0005657926,0.0009961682,0.0009285645,0.001935105,0.004608633],"category_scores_gemma":[0.002540067,0.0007380511,0.00232964,0.0004257172,0.001185755,0.001051807,0.0005506909,0.002180877,0.0005271249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007972574,"about_ca_system_score_gemma":0.001587163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009260843,"about_ca_topic_score_gemma":0.003088011,"domain_scores_codex":[0.9984509,0.0009719738,0.00009887853,0.0001823018,0.00009744439,0.0001984187],"domain_scores_gemma":[0.9982744,0.0005032556,0.0004155971,0.0001308206,0.0001471672,0.0005287573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9793107,0.008294269,0.0006790023,0.0008040491,0.0006343324,0.00004504955,0.00007255421,0.0001384326,0.002425259,0.00008615081,0.0003024678,0.007207642],"study_design_scores_gemma":[0.9432277,0.05498777,0.001036246,0.00002397027,0.0002134591,0.00001788136,0.00001423121,0.00008257412,0.0001443918,0.00005562607,0.0001896189,0.000006603488],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797013,0.00385209,0.0008368363,0.0004951032,0.0003449265,0.01256359,0.0009809557,0.00006941995,0.001155753],"genre_scores_gemma":[0.9789293,0.001976749,0.002789577,0.001111308,0.0003095894,0.01239975,0.0007292911,0.0000132861,0.001741166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004608633,"threshold_uncertainty_score":0.02114713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1119037683280759,"score_gpt":0.4390022127605437,"score_spread":0.3270984444324678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}