{"id":"W4412521658","doi":"10.1038/s42003-025-08491-0","title":"OICR-41103 as a chemical probe for the DCAF1 WD40 domain","year":2025,"lang":"en","type":"article","venue":"Communications Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; McGill University; Genentech; Government of Ontario; Bayer; Bristol-Myers Squibb; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Pfizer","keywords":"Ubiquitin ligase; Ubiquitin; Cell biology; Biology; Protein Data Bank (RCSB PDB); HEK 293 cells; Chemistry; Cell culture; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133064,0.0004387146,0.0001454856,0.0001739281,0.0001674189,0.0001528505,0.0004344275,0.0004335693,0.001572017],"category_scores_gemma":[0.00005956788,0.0001292745,0.0001749514,0.0001577765,0.0001747387,0.0001634691,0.0001873762,0.0005046038,0.0005608944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004289123,"about_ca_system_score_gemma":0.0003262681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008890257,"about_ca_topic_score_gemma":0.001173959,"domain_scores_codex":[0.9998968,0.00001607944,0.000004409483,0.0000258672,0.00002905301,0.00002781086],"domain_scores_gemma":[0.999965,0.000005906978,0.000009828665,0.000004865022,0.000004411719,0.00001003599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005606534,0.00003969892,0.00005641138,0.00006239342,0.000003421502,0.00009250913,0.00001283655,0.0002180396,0.9951739,0.0006972186,0.0001722008,0.00341537],"study_design_scores_gemma":[0.00002225643,0.0003212465,0.0003446376,0.000004593672,0.000004328162,0.0003359886,0.000006674454,0.0005549631,0.9928066,0.00004223682,0.005550396,0.000006050789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9326232,0.00763913,0.03542651,0.0007446093,0.0001154402,0.0002988809,0.0007553137,0.0004199208,0.02197714],"genre_scores_gemma":[0.9630982,0.004196247,0.01975713,0.00035648,0.00001902706,0.0001392012,0.0007349828,0.00002876411,0.01166996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001572017,"threshold_uncertainty_score":0.005258918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01726862705077209,"score_gpt":0.3299353447366977,"score_spread":0.3126667176859256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}