{"id":"W4412523022","doi":"10.1016/s1474-4422(25)00174-7","title":"Safety and efficacy of fenebrutinib in relapsing multiple sclerosis (FENopta): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial and open-label extension study","year":2025,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Roche","keywords":"Medicine; Clinical endpoint; Placebo; Internal medicine; Population; Expanded Disability Status Scale; Adverse effect; Clinical trial; Multiple sclerosis; Clinically isolated syndrome; Phases of clinical research; Surrogate endpoint; Physical therapy; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002961427,0.0002908516,0.002003628,0.000280117,0.0002737952,0.00005301115,0.0003514329,0.00013241,0.00001325211],"category_scores_gemma":[0.004232564,0.0001907022,0.00006449626,0.0004011107,0.0004254835,0.00008904345,0.0008508327,0.0006677711,0.000002014308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002797031,"about_ca_system_score_gemma":0.00009189765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004144736,"about_ca_topic_score_gemma":0.0004802515,"domain_scores_codex":[0.9964001,0.001192593,0.0008906167,0.0006697997,0.0002870824,0.0005598231],"domain_scores_gemma":[0.9933729,0.005445021,0.0002566446,0.0006831171,0.0001315415,0.0001108011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9651954,0.003529805,0.008435328,0.00005990965,0.0003416113,0.00003170842,0.0008699627,0.00003171454,0.008815478,0.00002572502,0.0002373507,0.01242606],"study_design_scores_gemma":[0.9467959,0.002980367,0.04239099,0.0001490552,0.0003049064,0.000007769835,0.0002174475,0.006606777,0.0001856941,0.00001061941,0.0002309874,0.0001194233],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763169,0.001642828,0.00002583857,0.005892599,0.0002644763,0.0153978,0.00001224658,0.00003527577,0.0004120135],"genre_scores_gemma":[0.9953236,0.003086303,0.0001358277,0.0007338412,0.0001379468,0.0004472697,0.000006356971,0.00002356176,0.0001052883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03395567,"threshold_uncertainty_score":0.7776608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1661435849068361,"score_gpt":0.4016988338568246,"score_spread":0.2355552489499884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}