{"id":"W4412526045","doi":"10.1002/pro.70223","title":"A multidomain hydrolase from the thermophile <i>Thermanaeromonas toyohensis</i> degrades high molecular mass forms of polyhydroxybutyrate","year":2025,"lang":"en","type":"article","venue":"Protein Science","topic":"biodegradable polymer synthesis and properties","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kimberly-Clark (Canada)","funders":"Georgia Institute of Technology; U.S. Department of Education","keywords":"Polyhydroxybutyrate; Thermophile; Hydrolase; Chemistry; Molecular mass; Biochemistry; Computational biology; Biophysics; Biology; Enzyme; Genetics; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001296506,0.0002459942,0.0003115508,0.00009571315,0.0004839078,0.0002187449,0.00161594,0.00007633504,0.000146196],"category_scores_gemma":[0.0002011279,0.0001392467,0.0000993603,0.0007308053,0.001547159,0.0003942733,0.0002949902,0.0001346064,0.00005025993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004629079,"about_ca_system_score_gemma":0.0002545167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002381968,"about_ca_topic_score_gemma":0.00005320116,"domain_scores_codex":[0.9975998,0.0001766369,0.0004260164,0.0005914301,0.000672705,0.0005333464],"domain_scores_gemma":[0.9985247,0.0001560177,0.0002059874,0.0009125565,0.000109751,0.00009099513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005298238,0.00004056311,0.0001741108,0.00001505475,0.000009969099,0.000004115982,0.0002646792,0.00000706558,0.9858248,0.005715313,0.00001626804,0.007875035],"study_design_scores_gemma":[0.0002266054,0.00004388371,0.0005359837,0.0001346239,0.00002175423,9.777269e-7,0.0001260897,0.0007025753,0.9842957,0.01351492,0.0002132864,0.0001836234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856173,0.008726517,0.001649067,0.00220909,0.0001988465,0.0005007643,0.00007695482,0.00006755858,0.0009539279],"genre_scores_gemma":[0.9953964,0.00001979381,0.003550819,0.0005924143,0.00002504731,0.0001334439,0.000001679411,0.00001459347,0.0002657563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009779179,"threshold_uncertainty_score":0.570057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008514994676955623,"score_gpt":0.2153916331813465,"score_spread":0.2068766385043909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}