{"id":"W4412529647","doi":"10.1016/j.biochi.2025.07.018","title":"Ribosome biogenesis is a therapeutic vulnerability in pediatric neuroblastoma","year":2025,"lang":"en","type":"article","venue":"Biochimie","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institut National Du Cancer; Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche; Ligue Contre le Cancer; Agence Nationale de la Recherche; Conseil National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Convergence","keywords":"Neuroblastoma; Ribosome biogenesis; Vulnerability (computing); Biogenesis; Medicine; Computational biology; Biology; Ribosome; Bioinformatics; Genetics; Computer science; RNA; Computer security","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005447294,0.0003571315,0.0005502533,0.0004855805,0.0005061979,0.0009953367,0.0002820505,0.0007258885,0.002003113],"category_scores_gemma":[0.001426719,0.000169471,0.0003555218,0.000571875,0.0006273566,0.0005585888,0.0006967182,0.0009551324,0.0004304174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001124649,"about_ca_system_score_gemma":0.001152186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001095372,"about_ca_topic_score_gemma":0.001347459,"domain_scores_codex":[0.9996137,0.00009653484,0.00003096581,0.00006840287,0.0001020583,0.00008839083],"domain_scores_gemma":[0.9993908,0.0001426063,0.000267484,0.00003438972,0.00008020173,0.00008448715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004024472,0.0003435777,0.1647639,0.002175851,0.0004824008,0.02423094,0.00158285,0.001887739,0.3865666,0.04036764,0.01726663,0.3563075],"study_design_scores_gemma":[0.0002637011,0.002824218,0.3706141,0.00183289,0.000922654,0.08664402,0.003806451,0.002710413,0.1645028,0.03852294,0.3272057,0.0001501345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7647595,0.1850917,0.005821213,0.01031567,0.0006751987,0.0000739891,0.00114791,0.0003621265,0.0317527],"genre_scores_gemma":[0.9556614,0.03810702,0.002236339,0.0007532968,0.0002223098,0.00004222758,0.0005900066,0.00005289957,0.002334679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002003113,"threshold_uncertainty_score":0.008159935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02166115366213828,"score_gpt":0.321732492939255,"score_spread":0.3000713392771168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}