{"id":"W4412529907","doi":"10.1016/j.clon.2025.103908","title":"Testing a 5-fraction Simultaneous Integrated Boost in Radiotherapy for Breast Cancer: The UK FAST-Forward Boost Trial Opens to Recruitment","year":2025,"lang":"en","type":"editorial","venue":"Clinical Oncology","topic":"Advanced Radiotherapy Techniques","field":"Physics and Astronomy","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"NIHR Cambridge Biomedical Research Centre; Health Technology Assessment Programme; Institute of Cancer Research; National Institute for Health and Care Research; Royal Marsden NHS Foundation Trust","keywords":"Medicine; Radiation therapy; Oncology; Breast cancer; Internal medicine; Cancer; Fraction (chemistry); Medical physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001818569,0.0006018709,0.001952623,0.000183564,0.0002149185,0.00008524016,0.0008980999,0.001230702,0.0002760096],"category_scores_gemma":[0.002543899,0.0004501381,0.0004879425,0.0004933013,0.0002156182,0.00007440001,0.0001385001,0.002374281,0.000005005732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001935161,"about_ca_system_score_gemma":0.00334678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001771811,"about_ca_topic_score_gemma":0.0005885159,"domain_scores_codex":[0.99529,0.0006916767,0.001948015,0.001082017,0.0003014158,0.0006868455],"domain_scores_gemma":[0.9691151,0.02840751,0.001038421,0.000661155,0.0005914414,0.0001863259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01990931,0.0004722097,0.0003597258,0.00001454605,0.0003163181,0.000007757741,0.00005193078,0.0003819522,0.00003970687,0.00005428161,0.4448777,0.5335146],"study_design_scores_gemma":[0.02070818,0.003821318,0.00004215661,0.0002849987,0.0001396916,0.000001089916,0.0000684599,0.001075554,0.00001481105,0.0004992236,0.9729027,0.0004418063],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.0008598118,0.000505372,0.1112649,0.004950609,0.8574955,0.01926957,0.003936536,0.0003666633,0.001350969],"genre_scores_gemma":[0.001179146,0.000718459,0.03914041,0.001560336,0.942095,0.01141218,0.000460967,0.0002343389,0.003199195],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.5330728,"threshold_uncertainty_score":0.9999273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07158612101273541,"score_gpt":0.4710126405851613,"score_spread":0.3994265195724259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}