{"id":"W4412531522","doi":"10.1073/pnas.2511507122","title":"Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and PARylation","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Sick Kids Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Nucleosome; Histone; Acetylation; Core (optical fiber); Modulation (music); Biophysics; Chemistry; Physics; Biology; Biochemistry; Optics; DNA; Gene; Acoustics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001738456,0.0001232088,0.0001516501,0.00005255295,0.0000864881,0.0002193456,0.0001717611,0.0002012015,0.0006188528],"category_scores_gemma":[0.0002133956,0.0001197195,0.0001085833,0.00006567041,0.0002525505,0.0001988865,0.0001347971,0.0003878832,0.0001326701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001559859,"about_ca_system_score_gemma":0.0001078785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005148101,"about_ca_topic_score_gemma":0.0006979513,"domain_scores_codex":[0.9999299,0.00001472556,0.000003984486,0.00001728384,0.00001701576,0.00001712705],"domain_scores_gemma":[0.999909,0.00002768062,0.00002780001,0.000006437621,0.000009237257,0.00001988508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007858656,0.000009051854,0.00009696097,0.00001295479,0.000002856377,0.000008876496,0.00001053643,0.00006204738,0.9990834,0.00005555021,0.000008222816,0.0005708724],"study_design_scores_gemma":[0.00001524032,0.0001769832,0.001608902,0.000002113806,0.000005967081,0.0000340084,0.00001733926,0.001766978,0.9959383,0.00004495329,0.000383795,0.000005464495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967398,0.0004329864,0.002215734,0.00004569934,0.00001689696,0.000008199328,0.00004091095,0.00001478257,0.0004850331],"genre_scores_gemma":[0.9979533,0.000261326,0.001265961,0.00004283081,0.00000574054,0.000006280954,0.00004454686,0.000008225532,0.0004116869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006188528,"threshold_uncertainty_score":0.002070248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362408658385611,"score_gpt":0.2956485931717341,"score_spread":0.282024506587878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}