{"id":"W4412534301","doi":"10.1016/s2468-1253(25)00129-3","title":"Anti-TL1A antibody, afimkibart, in moderately-to-severely active ulcerative colitis (TUSCANY-2): a multicentre, double-blind, treat-through, multi-dose, randomised, placebo-controlled, phase 2b trial","year":2025,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Genentech; F. Hoffmann-La Roche; Roche; Pfizer","keywords":"Ulcerative colitis; Medicine; Double blind; Placebo; Gastroenterology; Internal medicine; Traditional medicine; Alternative medicine; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001322679,0.001755508,0.002609582,0.0004012478,0.0003815883,0.0009617534,0.0008490337,0.002206544,0.005847426],"category_scores_gemma":[0.001067904,0.0005123514,0.001507067,0.0004131172,0.0009390205,0.0007282982,0.0003518966,0.002572266,0.0009857715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007172997,"about_ca_system_score_gemma":0.0005753911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001597553,"about_ca_topic_score_gemma":0.003155645,"domain_scores_codex":[0.9996682,0.0001678599,0.00001494512,0.00005040703,0.00002310713,0.00007550122],"domain_scores_gemma":[0.9994826,0.0001433861,0.0001208632,0.00003296103,0.00003303263,0.0001872316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9693906,0.002124989,0.0008102222,0.001265923,0.001152626,0.00007768261,0.00004587101,0.0002290377,0.003778236,0.00008734808,0.001722193,0.01931529],"study_design_scores_gemma":[0.9519106,0.04238119,0.003660844,0.00006310919,0.000570382,0.00007471052,0.00002755685,0.0002228545,0.000283053,0.00007599669,0.000717583,0.00001232815],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691272,0.02329235,0.000426883,0.001522725,0.0008713397,0.001129659,0.0009727986,0.0002054124,0.002451752],"genre_scores_gemma":[0.9820708,0.007834613,0.0008363927,0.001633062,0.0007484606,0.001276191,0.001279302,0.00002825858,0.004292966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005847426,"threshold_uncertainty_score":0.01956159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02468209004545791,"score_gpt":0.3290040073065103,"score_spread":0.3043219172610524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}