{"id":"W4412535807","doi":"10.1016/j.breast.2025.104545","title":"Biomarkers of response and resistance to immune checkpoint inhibitors in breast cancer","year":2025,"lang":"en","type":"review","venue":"The Breast","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Santé Montérégie","funders":"","keywords":"Medicine; Breast cancer; Oncology; Cancer; Immune system; Cancer research; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007288838,0.0008415122,0.001614181,0.00204821,0.0001345139,0.0007580915,0.0006063993,0.000780989,0.002229325],"category_scores_gemma":[0.0008733664,0.0002482107,0.0006635917,0.001528862,0.000266667,0.0007237393,0.0004934194,0.001329539,0.001216421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005847798,"about_ca_system_score_gemma":0.0007389523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008604242,"about_ca_topic_score_gemma":0.001539622,"domain_scores_codex":[0.9997557,0.00006328282,0.00003692121,0.00003719198,0.00008532202,0.0000215761],"domain_scores_gemma":[0.9996586,0.0001702242,0.00006115791,0.000007786539,0.0000867132,0.00001552825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009119725,0.000048331,0.0003013285,0.0142954,0.0001607536,0.00007895679,0.00002926518,0.0002893672,0.001078843,0.001522429,0.01585406,0.9662502],"study_design_scores_gemma":[0.00004750284,0.0002440548,0.002922414,0.01113617,0.0004681039,0.001420054,0.00006200746,0.0002334691,0.0008473095,0.002029798,0.9805567,0.00003241381],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001007245,0.9990429,0.00007291546,0.000151039,0.00009859657,0.000004791012,0.00001888098,0.000004107631,0.0005059688],"genre_scores_gemma":[0.0008707962,0.9982015,0.0001662398,0.0001781274,0.000090063,0.00001015317,0.00004421987,0.000001165225,0.0004376899],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002229325,"threshold_uncertainty_score":0.007457852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01624044365856079,"score_gpt":0.3144966989818271,"score_spread":0.2982562553232663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}