{"id":"W4412538727","doi":"10.1016/j.ekir.2025.07.015","title":"Novel Treatment Paradigms: Complement Inhibition in Antineutrophil Cytoplasmic Autoantibody Vasculitis","year":2025,"lang":"en","type":"review","venue":"Kidney International Reports","topic":"Vasculitis and related conditions","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Medicine; ANCA-Associated Vasculitis; Complement (music); Vasculitis; Immunology; Dermatology; Internal medicine; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001747301,0.0004916103,0.000933232,0.000778264,0.0002956568,0.001107052,0.0007490944,0.001260841,0.004064289],"category_scores_gemma":[0.001004158,0.0001352831,0.000802919,0.000438169,0.0006188744,0.001249346,0.000601567,0.002623606,0.001073895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008647063,"about_ca_system_score_gemma":0.001081184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005664001,"about_ca_topic_score_gemma":0.001693437,"domain_scores_codex":[0.9993514,0.000246531,0.00006894067,0.00008500137,0.0001801125,0.00006792494],"domain_scores_gemma":[0.9995426,0.0002292525,0.00006397638,0.00001759322,0.0001014147,0.00004523182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007755007,0.0003435599,0.0003295433,0.02200875,0.0002682313,0.000658372,0.0001623102,0.0006039352,0.01013043,0.02233446,0.03726945,0.9051154],"study_design_scores_gemma":[0.0004227269,0.001602789,0.001504695,0.007614064,0.0003806569,0.002854491,0.0001509778,0.0004548972,0.004189521,0.01269388,0.9680807,0.0000507679],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001546985,0.9854503,0.001497837,0.005149635,0.001465694,0.0000602878,0.0000549144,0.00003486959,0.004739528],"genre_scores_gemma":[0.01962283,0.9668635,0.00289623,0.005711197,0.002238287,0.0001499728,0.0001577087,0.00001271625,0.002347665],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004064289,"threshold_uncertainty_score":0.01359642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03193011177742495,"score_gpt":0.3482504228940109,"score_spread":0.316320311116586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}