{"id":"W4412541899","doi":"10.1002/adhm.202502019","title":"Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting <i>KMT2A::AFF1</i> with Enhanced Extrahepatic Delivery","year":2025,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; University of Alberta","funders":"Canadian Institutes of Health Research; Edmonton Civic Employees Charitable Assistance Fund; Canadian Cancer Society; Mitacs; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Gene silencing; Biodistribution; Polyethylenimine; Leukemia; Apoptosis; In vivo; Peripheral blood mononuclear cell; Cancer research; Bone marrow; Chemistry; Small interfering RNA; In vitro; Molecular biology; Medicine; Immunology; Transfection; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001891501,0.0003270265,0.0004986989,0.00007096897,0.0001780392,0.00004576285,0.0003036248,0.0002037218,0.00004813233],"category_scores_gemma":[0.00003675041,0.0002986953,0.0000828538,0.000173514,0.0001392336,0.00003754702,0.000157962,0.00009327678,0.000007425192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000717476,"about_ca_system_score_gemma":0.0003355436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000570004,"about_ca_topic_score_gemma":0.0001535225,"domain_scores_codex":[0.9977782,0.000164642,0.0006901931,0.000605277,0.0001950287,0.0005666242],"domain_scores_gemma":[0.9987248,0.00003700083,0.0003212738,0.0004941989,0.0003066767,0.0001160784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008466372,0.00004618676,0.0003486978,0.0002299371,0.0001095549,0.000006179727,0.00009243981,0.00007225206,0.9927967,0.00002469343,0.001532101,0.003894643],"study_design_scores_gemma":[0.0009015381,0.0005012361,0.0001022451,0.0003387378,0.00006357264,0.000005017672,0.0002015877,0.00001350723,0.995968,0.00005697729,0.001545917,0.0003016329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941422,0.003550374,0.0008395516,0.0003058561,0.0004339468,0.000383013,0.0002093732,0.00003741556,0.00009828014],"genre_scores_gemma":[0.9949551,0.00134109,0.001348306,0.001182465,0.00008896682,0.00008118041,0.0003256606,0.00004183953,0.0006354219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00359301,"threshold_uncertainty_score":0.9999465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004783247109285742,"score_gpt":0.2527689936604774,"score_spread":0.2479857465511917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}