{"id":"W4412546169","doi":"10.1111/pbi.70278","title":"Structural Design and Immunogenicity of a Novel Self‐Adjuvanting Mucosal Vaccine Candidate for <scp>SARS</scp> ‐ <scp>CoV</scp> ‐2 Expressed in Plants","year":2025,"lang":"en","type":"article","venue":"Plant Biotechnology Journal","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Immunogenicity; Immune system; Biology; Antibody; Antigen; Vaccination; Virology; Immunology; Context (archaeology); Cholera toxin; Microbiology; Immunity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003498244,0.0002395022,0.0003636672,0.0002609415,0.0001910533,0.00003058389,0.000409969,0.0005307722,4.896214e-7],"category_scores_gemma":[0.0002268042,0.0002138134,0.00008501942,0.0001597918,0.00008089961,0.00001088467,0.0001168045,0.0003980809,3.518216e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000182694,"about_ca_system_score_gemma":0.0001507673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000372786,"about_ca_topic_score_gemma":0.00007827088,"domain_scores_codex":[0.9985123,0.00004248576,0.0005147802,0.0003766259,0.00008939569,0.0004644102],"domain_scores_gemma":[0.9991512,0.0002171046,0.0002722475,0.0002507935,0.00005461196,0.00005409003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005767667,0.00008467434,0.002827435,0.00003806942,0.0001996504,0.000008042261,0.00007611345,0.00008106993,0.9945281,0.000229451,0.001038355,0.0008313892],"study_design_scores_gemma":[0.003397826,0.0001667514,0.005827734,0.00007993956,0.00006558518,0.0006680471,0.000210786,0.002675478,0.977906,0.0003271028,0.008608931,0.0000658273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.957645,0.001926541,0.0388601,0.0001821934,0.0001164093,0.0003998287,0.0008131354,0.000031158,0.00002562686],"genre_scores_gemma":[0.9857619,0.002017868,0.01185557,0.00008430149,0.00004872385,0.00002993912,0.0001472735,0.00001740262,0.00003700927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02811691,"threshold_uncertainty_score":0.8719057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01331031153705525,"score_gpt":0.2485226683260306,"score_spread":0.2352123567889754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}