{"id":"W4412546537","doi":"10.3389/fnagi.2025.1637368","title":"miR-423-5p and miR-92a-3p in Alzheimer’s disease: relationship with pathology and cognition","year":2025,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Eisai; Meso Scale Diagnostics; National Research Foundation of Korea; Servier; Soonchunhyang University; National Research Foundation; Northern California Institute for Research and Education; BioClinica; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Ministry of Science and ICT, South Korea; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Association","keywords":"Neurodegeneration; Cognition; microRNA; Dementia; Disease; Cognitive decline; Psychology; Neuroimaging; Oncology; Bioinformatics; Neuroscience; Biology; Internal medicine; Gene; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008691095,0.0004483222,0.0002810093,0.000681435,0.0002796201,0.000626535,0.0002156194,0.0003676507,0.0007820998],"category_scores_gemma":[0.001787915,0.000229543,0.0004496149,0.0007553873,0.0003017241,0.0001836908,0.0003280071,0.0004957769,0.0001837755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001999181,"about_ca_system_score_gemma":0.0002219603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001136062,"about_ca_topic_score_gemma":0.001080947,"domain_scores_codex":[0.9996328,0.0001081429,0.00003146612,0.0001115874,0.0000816922,0.00003424389],"domain_scores_gemma":[0.999083,0.0003157155,0.0003314399,0.00007247668,0.0001010413,0.00009625676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002658109,0.0001423785,0.9588991,0.00008038312,0.0006775768,0.0003261026,0.0002916785,0.0007119435,0.01832443,0.0001462372,0.0002073251,0.01753466],"study_design_scores_gemma":[0.00001777092,0.0001092029,0.996074,0.00000496596,0.0001294494,0.0004539413,0.00005427347,0.0008369663,0.001804212,0.0002457752,0.0002633594,0.000006226767],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981667,0.0007175437,0.0004760301,0.00003685686,0.000004355851,0.000006674492,0.0001803812,0.00001291536,0.0003984756],"genre_scores_gemma":[0.9989666,0.0001244327,0.0006766487,0.00001002986,0.00000650213,0.000007856453,0.0001050788,0.000002982013,0.00009986444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001136062,"threshold_uncertainty_score":0.004596353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01330247389901889,"score_gpt":0.2560883168436227,"score_spread":0.2427858429446038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}