{"id":"W4412549698","doi":"10.1038/s41583-025-00946-x","title":"Top-down and bottom-up neuroscience: overcoming the clash of research cultures","year":2025,"lang":"en","type":"review","venue":"Nature reviews. Neuroscience","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Top-down and bottom-up design; Neuroscience; Cognitive science; Psychology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.006211136,0.001564661,0.003670289,0.003377779,0.0007409651,0.004174016,0.003179123,0.004234219,0.003600827],"category_scores_gemma":[0.005348317,0.0005627949,0.0008552122,0.002787652,0.005412847,0.008953758,0.003304641,0.008364491,0.002483821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002809544,"about_ca_system_score_gemma":0.00418249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001569584,"about_ca_topic_score_gemma":0.003427623,"domain_scores_codex":[0.9984716,0.000537206,0.0001470984,0.0002171328,0.0005071851,0.0001198072],"domain_scores_gemma":[0.9929027,0.005297314,0.0002427141,0.0002344271,0.0009243751,0.0003983745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000124232,0.00005749917,0.0001700408,0.01553549,0.0001730265,0.0001851005,0.0002063831,0.0004468338,0.001087587,0.07900025,0.1084488,0.7945648],"study_design_scores_gemma":[0.00002466112,0.00007099732,0.0005968692,0.008325742,0.0001003303,0.0006535828,0.0002183655,0.0001957306,0.0003016579,0.07607047,0.9133964,0.00004518428],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003508808,0.992916,0.0004864288,0.004657011,0.0009159648,0.00000240324,0.00001092732,0.00001711948,0.0009590819],"genre_scores_gemma":[0.0009557249,0.9927771,0.0007420138,0.003177136,0.001788596,0.00001195212,0.00002046617,0.00001192248,0.0005150962],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9992591,"threshold_uncertainty_score":0.032848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1471953017233788,"score_gpt":0.4608088716079077,"score_spread":0.3136135698845289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}