{"id":"W4412555291","doi":"10.1016/j.jvir.2025.07.010","title":"First-in-Human Evaluation of a New Resorbable Microspherical Embolic Agent for Genicular Artery Embolization to Treat Pain Secondary to Knee Osteroarthritis","year":2025,"lang":"en","type":"article","venue":"Journal of Vascular and Interventional Radiology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Innovation Council and Small and Medium-sized Enterprises Executive Agency; HORIZON EUROPE European Innovation Council; Executive Agency for Small and Medium-sized Enterprises; European Commission","keywords":"Medicine; WOMAC; Osteoarthritis; Visual analogue scale; Adverse effect; Clinical endpoint; Surgery; Embolization; Pain score; Randomized controlled trial; Anesthesia; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004732612,0.001651273,0.001998364,0.0004422973,0.0003961837,0.0009245445,0.0008697171,0.001455215,0.00251929],"category_scores_gemma":[0.002530577,0.0006628342,0.001110018,0.0002714399,0.00159051,0.0009303045,0.0002742804,0.00188664,0.0005564927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003735689,"about_ca_system_score_gemma":0.0007675436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002964428,"about_ca_topic_score_gemma":0.0005261661,"domain_scores_codex":[0.9979442,0.001228448,0.0001234658,0.0002775439,0.0002464359,0.0001798445],"domain_scores_gemma":[0.9981095,0.0005084421,0.000633875,0.0002870748,0.0001824677,0.0002786182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4723668,0.1357801,0.005005966,0.002735919,0.001466058,0.0004333009,0.0006018467,0.001248089,0.2682846,0.0003581382,0.001358597,0.1103605],"study_design_scores_gemma":[0.04760594,0.9240408,0.004160365,0.00002775852,0.0004211204,0.0002873859,0.00004371137,0.0005986005,0.02137531,0.00006948176,0.001347844,0.00002172568],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925563,0.002383114,0.00249405,0.0001153049,0.0001384849,0.001612902,0.0002104143,0.00006522149,0.0004243155],"genre_scores_gemma":[0.9909497,0.001877031,0.003414183,0.0003364717,0.0004244967,0.001252843,0.0004646091,0.00003171348,0.001249024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004732612,"threshold_uncertainty_score":0.02502871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02002742146030627,"score_gpt":0.3097758197265745,"score_spread":0.2897483982662682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}